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3. Pathway-based targets
3.2. Characteristic features of pathway-based drug targets
| No. | KEGG ID | Protein Name | KO Number | Pathway | Pathway ID | NCBI Protein ID | Length (a.a.) | Chokepoint Enzyme | Virulence Factor |
| 1 | CJE1596 | holo-(acyl-carrier-protein) synthase | K00997
| Pantothenate and CoA biosynthesis | cjr00770 | AAW36029 | 115 | Yes | No |
| 2 | CJE1405 | N-acetylmuramoyl-L-alanine amidase | K01448
| Cationic antimicrobial peptide resistance | cjr01503 | AAW35724 | 659 | Yes | No
|
| 3 | CJE1810 | DNA primase | K02316 | DNA replication | cjr03030 | AAW36232 | 605 | No | Yes |
| 4 | CJE1654 | ATP-dependent DNA helicase, UvrD/REP family | K03582 | Homologous recombination | cjr03440 | AAW36087 | 921 | No | Yes |
| 5 | CJE1566 | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | K02428 | Purine metabolism | cjr00230 | AAW36001 | 200 | No | Yes |
| 6 | CJE1554 | Holliday junction DNA helicase RuvB | K03551 | Homologous recombination | cjr03440 | AAW35989 | 335 | No | Yes |
| 7 | CJE1486 | aminotransferase, DegT/DnrJ/EryC1/StrS family | K15895 | Amino sugar and nucleotide sugar metabolism | cjr00520 | AAW35927 | 376 | No | Yes |
| 8 | CJE0667 | replicative DNA helicase | K02314 | DNA replication | cjr03030 | AAW35822 | 458 | No | Yes |
| 9 | CJE0684 | (di)nucleoside polyphosphate hydrolase | K08311 | RNA degradation | cjr03018 | AAW35806 | 156
| No | Yes |
| 10 | CJE1406 | oxidoreductase, 2-nitropropane dioxygenase family | K00459 | Nitrogen metabolism | cjr00910 | AAW35725 | 363 | No | Yes |
| 11 | CJE1401 | quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit | K03620 | Two-component system | cjr02020 | AAW35720 | 238 | No | Yes |
| 12 | CJE1382 | excinuclease ABC, C subunit | K03703 | Nucleotide excision repair | cjr03420 | AAW35702 | 600 | No | Yes |
| 13 | CJE1343 | HD/HDIG/KH domain protein | K18682 | RNA degradation | cjr03018 | AAW35664 | 517 | No | Yes |
| 14 | CJE1292 | transcription termination factor Rho | K03628 | RNA degradation | cjr03018 | AAW35614 | 432 | No | Yes |
| 15 | CJE1264 | general glycosylation pathway protein | K15910 | Amino sugar and nucleotide sugar metabolism | cjr00520 | AAW35586 | 386 | No | Yes |
| 16 | CJE1228 | transcription-repair coupling factor | K03723 | Nucleotide excision repair | cjr03420 | AAW35550 | 978 | No | Yes |
| 17 | CJE1196 | DNA mismatch repair protein | K07456 | Mismatch repair | cjr03430 | AAW35521 | 735 | No | Yes |
| 18 | CJE1067 | hippurate hydrolase | K01451 | Phenylalanine metabolism | cjr00360 | AAW35395 | 383 | No | Yes |
| 19 | CJE0993 | thioesterase family protein | K10806 | Biosynthesis of unsaturated fatty acids | cjr01040 | AAW35326 | 137 | No | Yes |
| 20 | CJE0966 | flagellin family protein | K02397 | Flagellar assembly | cjr02040 | AAW35299 | 750 | No | Yes |
| 21 | CJE0951 | thiol:disulfide interchange protein DsbA | K03673 | Cationic antimicrobial peptide (CAMP) resistance | cjr01503 | AAW35288 | 220 | No | Yes |
| 22 | CJE0949 | para-aminobenzoate synthase glutamine amidotransferase, component I | K03342 | Folate biosynthesis | cjr00790 | AAW35286 | 594 | No | Yes |
| 23 | CJE0943 | signal peptidase I | K03100 | Protein export | cjr03060 | AAW35280 | 282 | No | Yes |
| 24 | CJE0892 | integral membrane protein MviN | K03980 | Peptidoglycan biosynthesis | cjr00550 | AAW35229 | 483 | No | Yes |
| 25 | CJE0890 | Holliday junction DNA helicase RuvA | K03550 | Homologous recombination | cjr03440 | AAW35227 | 183 | No | Yes |
| 26 | CJE0860 | flagellar basal-body P-ring formation protein FlgA, putative | K02386 | Flagellar assembly | cjr02040 | AAW35197 | 220 | No | Yes |
| 27 | CJE0514 | ATP-dependent DNA helicase RecG | K03655 | Homologous recombination | cjr03440 | AAW35101 | 607 | No | Yes |
| 28 | CJE0410 | lipoprotein signal peptidase | K03101 | Protein export | cjr03060 | AAW34999 | 156 | No | Yes |
| 29 | CJE0402 | phosphatase, Ppx/GppA family | K01524 | Purine metabolism | cjr00230 | AAW34991 | 486 | No | Yes |
| 30 | CJE0390 | excinuclease ABC, A subunit | K03701 | Nucleotide excision repair | cjr03420 | AAW34979 | 940 | No | Yes |
| 31 | CJE0288 | carbonic anhydrase | K01673 | Nitrogen metabolism | cjr00910 | AAW34880 | 211 | No | Yes |
| 32 | CJE0782 | primosomal protein N' | K04066 | Homologous recombination | cjr03440 | AAW34570 | 617 | No | Yes |
| 33 | CJE0771 | RNA polymerase sigma-54 factor | K03092 | Two-component system | cjr02020 | AAW34562 | 416 | No | Yes |
| 34 | CJE1897 | crossover junction endodeoxyribonucleaseRuvC | K01159 | Homologous recombination | cjr03440 | AAW34497 | 160 | No | Yes |
| 35 | CJE1845 | RecA | K03553 | Homologous recombination | cjr03440 | AAW36267 | 343 | No | Yes |
| 36 | CJE0001 | chromosomal replication initiator protein DnaA | K02313 | Two-component system | cjr02020 | AAW34498 | 440 | No | Yes |
| 37 | CJE0198 | undecaprenol kinase, putative | K06153 | Peptidoglycan biosynthesis | cjr00550 | AAW34792 | 267 | No | Yes |
| 38 | CJE0406 | Conserved hypothetical ProteinTIGR00023 | K08591 | Glycerolipid metabolism | cjr00561 | AAW34995.1 | 202 | No | Yes |