Therapeutic Targets

No.	Protein ID	Protein Name
1	sp\|Q5HT08\|ACPS_CAMJR	Holo-[acyl-carrier-protein] synthase
2	gi\|57166945\|gb\|AAW35724.1\|	N-acetylmuramoyl-L-alanine amidase
3	gi\|57167453\|gb\|AAW36232.1\|	DNA primase
4	gi\|57167308\|gb\|AAW36087.1\|	ATP-dependent DNA helicase, UvrD/REP family
5	gi\|57167222\|gb\|AAW36001.1\|	non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
6	gi\|57167210\|gb\|AAW35989.1\|	Holliday junction DNA helicase RuvB
7	gi\|57167148\|gb\|AAW35927.1\|	aminotransferase, DegT/DnrJ/EryC1/StrS family
8	gi\|57167043\|gb\|AAW35822.1\|	replicative DNA helicase
9	gi\|57167027\|gb\|AAW35806.1\|	(di)nucleoside polyphosphate hydrolase
10	gi\|57166946\|gb\|AAW35725.1\|	oxidoreductase, 2-nitropropane dioxygenase family
11	gi\|57166941\|gb\|AAW35720.1\|	quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit
12	gi\|57166923\|gb\|AAW35702.1\|	excinuclease ABC, C subunit
13	gi\|57166885\|gb\|AAW35664.1\|	HD/HDIG/KH domain protein
14	gi\|57166835\|gb\|AAW35614.1\|	transcription termination factor Rho
15	gi\|57166807\|gb\|AAW35586.1\|	general glycosylation pathway protein
16	gi\|57166771\|gb\|AAW35550.1\|	transcription-repair coupling factor
17	gi\|57166742\|gb\|AAW35521.1\|	DNA mismatch repair protein
18	gi\|57166616\|gb\|AAW35395.1\|	hippurate hydrolase
19	gi\|57166547\|gb\|AAW35326.1\|	thioesterase family protein
20	gi\|57166520\|gb\|AAW35299.1\|	flagellin family protein
21	gi\|57166509\|gb\|AAW35288.1\|	thiol:disulfide interchange protein DsbA
22	gi\|57166507\|gb\|AAW35286.1\|	para-aminobenzoate synthase glutamine amidotransferase, component I
23	gi\|57166501\|gb\|AAW35280.1\|	signal peptidase I
24	gi\|57166450\|gb\|AAW35229.1\|	integral membrane protein MviN
25	gi\|57166448\|gb\|AAW35227.1\|	Holliday junction DNA helicase RuvA
26	gi\|57166418\|gb\|AAW35197.1\|	flagellar basal-body P-ring formation protein FlgA, putative
27	gi\|57166322\|gb\|AAW35101.1\|	ATP-dependent DNA helicase RecG
28	gi\|57166220\|gb\|AAW34999.1\|	lipoprotein signal peptidase
29	gi\|57166212\|gb\|AAW34991.1\|	phosphatase, Ppx/GppA family
30	gi\|57166200\|gb\|AAW34979.1\|	excinuclease ABC, A subunit
31	gi\|57166101\|gb\|AAW34880.1\|	carbonic anhydrase
32	gi\|57165791\|gb\|AAW34570.1\|	primosomal protein N'
33	gi\|57165783\|gb\|AAW34562.1\|	RNA polymerase sigma-54 factor
34	gi\|57165718\|gb\|AAW34497.1\|	crossover junction endodeoxyribonuclease RuvC
35	gi\|76363322\|sp\|Q5HSC0.1\|	Protein RecA
36	gi\|71151795\|sp\|Q5HXF5.1\|	Chromosomal replication initiator protein DnaA
37	gi\|68566122\|sp\|Q5HWW4.1\|	Undecaprenyl-diphosphatase
38	gi\|57166216\|gb\|AAW34995.1\|	conserved hypothetical protein TIGR00023

2. Druggability of drug targets Back to therapeutic targets

No.	Protein	E Value	Drug name
1	sp\|Q5HT08\|ACPS_CAMJR	1.30033e-11	Coenzyme A
			1,4-Dithiothreitol
2	gi\|57166945\|gb\|AAW35724.1\|	Novel
3	gi\|57167453\|gb\|AAW36232.1\|	Novel
4	gi\|57167308\|gb\|AAW36087.1\|	Novel
5	gi\|57167222\|gb\|AAW36001.1\|	Novel
6	gi\|57167210\|gb\|AAW35989.1\|	4.143e-106	Adenine
7	gi\|57167148\|gb\|AAW35927.1\|	2.38885e-45	Pyridoxamine-5'-Phosphate
			Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate
8	gi\|57167043\|gb\|AAW35822.1\|	Novel
9	gi\|57167027\|gb\|AAW35806.1\|	Novel
10	gi\|57166946\|gb\|AAW35725.1\|	Novel
11	gi\|57166941\|gb\|AAW35720.1\|	Novel
12	gi\|57166923\|gb\|AAW35702.1\|	Novel
13	gi\|57166885\|gb\|AAW35664.1\|	Novel
14	gi\|57166835\|gb\|AAW35614.1\|	Novel
15	gi\|57166807\|gb\|AAW35586.1\|	Experimental
16	gi\|57166771\|gb\|AAW35550.1\|	Novel
17	gi\|57166742\|gb\|AAW35521.1\|	Novel
18	gi\|57166616\|gb\|AAW35395.1\|	Novel
19	gi\|57166547\|gb\|AAW35326.1\|	2.39426e-33	Coenzyme A
		1.22552e-15	Coenzyme A
		2.85073e-13	Coenzyme A
20	gi\|57166520\|gb\|AAW35299.1\|	Novel
21	gi\|57166509\|gb\|AAW35288.1\|	Experimental
22	gi\|57166507\|gb\|AAW35286.1\|	Experimental
23	gi\|57166501\|gb\|AAW35280.1\|	Experimental
24	gi\|57166450\|gb\|AAW35229.1\|	Novel
25	gi\|57166448\|gb\|AAW35227.1\|	Novel
26	gi\|57166418\|gb\|AAW35197.1\|	Novel
27	gi\|57166322\|gb\|AAW35101.1\|	Novel
28	gi\|57166220\|gb\|AAW34999.1\|	Novel
29	gi\|57166212\|gb\|AAW34991.1\|	Experimental
30	gi\|57166200\|gb\|AAW34979.1\|	4.69336e-07	Colchicine
			Silodosin
			Etravirine
		1.0096e-06	Doxorubicin
		2.34716e-06	Gramicidin D
			Cyclosporine
			Adenosine triphosphate
			Pravastatin
			Fluvoxamine
			Fluconazole
			Erythromycin
			Erythromycin
			Caffeine
			Reserpine
31	gi\|57166101\|gb\|AAW34880.1\|	Novel
32	gi\|57165791\|gb\|AAW34570.1\|	Novel
33	gi\|57165783\|gb\|AAW34562.1\|	Novel
34	gi\|57165718\|gb\|AAW34497.1\|	Novel
35	gi\|76363322\|sp\|Q5HSC0.1\|	Experimental
36	gi\|71151795\|sp\|Q5HXF5.1\|	Novel
37	gi\|68566122\|sp\|Q5HWW4.1\|	Novel
38	gi\|57166216\|gb\|AAW34995.1\|	Novel

3. Pathway-based targets Back to therapeutic targets

3.1. List of pathway-based drug targets

No.	KEGG ID	Protein Name	KO Number	Pathway	Pathway ID	NCBI Protein ID	Length (a.a.)	Chokepoint Enzyme	Virulence Factor
1	CJE1596	holo-(acyl-carrier-protein) synthase	K00997	Pantothenate and CoA biosynthesis	cjr00770	AAW36029	115	Yes	No
2	CJE1405	N-acetylmuramoyl-L-alanine amidase	K01448	Cationic antimicrobial peptide resistance	cjr01503	AAW35724	659	Yes	No
3	CJE1810	DNA primase	K02316	DNA replication	cjr03030	AAW36232	605	No	Yes
4	CJE1654	ATP-dependent DNA helicase, UvrD/REP family	K03582	Homologous recombination	cjr03440	AAW36087	921	No	Yes
5	CJE1566	non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family	K02428	Purine metabolism	cjr00230	AAW36001	200	No	Yes
6	CJE1554	Holliday junction DNA helicase RuvB	K03551	Homologous recombination	cjr03440	AAW35989	335	No	Yes
7	CJE1486	aminotransferase, DegT/DnrJ/EryC1/StrS family	K15895	Amino sugar and nucleotide sugar metabolism	cjr00520	AAW35927	376	No	Yes
8	CJE0667	replicative DNA helicase	K02314	DNA replication	cjr03030	AAW35822	458	No	Yes
9	CJE0684	(di)nucleoside polyphosphate hydrolase	K08311	RNA degradation	cjr03018	AAW35806	156	No	Yes
10	CJE1406	oxidoreductase, 2-nitropropane dioxygenase family	K00459	Nitrogen metabolism	cjr00910	AAW35725	363	No	Yes
11	CJE1401	quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit	K03620	Two-component system	cjr02020	AAW35720	238	No	Yes
12	CJE1382	excinuclease ABC, C subunit	K03703	Nucleotide excision repair	cjr03420	AAW35702	600	No	Yes
13	CJE1343	HD/HDIG/KH domain protein	K18682	RNA degradation	cjr03018	AAW35664	517	No	Yes
14	CJE1292	transcription termination factor Rho	K03628	RNA degradation	cjr03018	AAW35614	432	No	Yes
15	CJE1264	general glycosylation pathway protein	K15910	Amino sugar and nucleotide sugar metabolism	cjr00520	AAW35586	386	No	Yes
16	CJE1228	transcription-repair coupling factor	K03723	Nucleotide excision repair	cjr03420	AAW35550	978	No	Yes
17	CJE1196	DNA mismatch repair protein	K07456	Mismatch repair	cjr03430	AAW35521	735	No	Yes
18	CJE1067	hippurate hydrolase	K01451	Phenylalanine metabolism	cjr00360	AAW35395	383	No	Yes
19	CJE0993	thioesterase family protein	K10806	Biosynthesis of unsaturated fatty acids	cjr01040	AAW35326	137	No	Yes
20	CJE0966	flagellin family protein	K02397	Flagellar assembly	cjr02040	AAW35299	750	No	Yes
21	CJE0951	thiol:disulfide interchange protein DsbA	K03673	Cationic antimicrobial peptide (CAMP) resistance	cjr01503	AAW35288	220	No	Yes
22	CJE0949	para-aminobenzoate synthase glutamine amidotransferase, component I	K03342	Folate biosynthesis	cjr00790	AAW35286	594	No	Yes
23	CJE0943	signal peptidase I	K03100	Protein export	cjr03060	AAW35280	282	No	Yes
24	CJE0892	integral membrane protein MviN	K03980	Peptidoglycan biosynthesis	cjr00550	AAW35229	483	No	Yes
25	CJE0890	Holliday junction DNA helicase RuvA	K03550	Homologous recombination	cjr03440	AAW35227	183	No	Yes
26	CJE0860	flagellar basal-body P-ring formation protein FlgA, putative	K02386	Flagellar assembly	cjr02040	AAW35197	220	No	Yes
27	CJE0514	ATP-dependent DNA helicase RecG	K03655	Homologous recombination	cjr03440	AAW35101	607	No	Yes
28	CJE0410	lipoprotein signal peptidase	K03101	Protein export	cjr03060	AAW34999	156	No	Yes
29	CJE0402	phosphatase, Ppx/GppA family	K01524	Purine metabolism	cjr00230	AAW34991	486	No	Yes
30	CJE0390	excinuclease ABC, A subunit	K03701	Nucleotide excision repair	cjr03420	AAW34979	940	No	Yes
31	CJE0288	carbonic anhydrase	K01673	Nitrogen metabolism	cjr00910	AAW34880	211	No	Yes
32	CJE0782	primosomal protein N'	K04066	Homologous recombination	cjr03440	AAW34570	617	No	Yes
33	CJE0771	RNA polymerase sigma-54 factor	K03092	Two-component system	cjr02020	AAW34562	416	No	Yes
34	CJE1897	crossover junction endodeoxyribonucleaseRuvC	K01159	Homologous recombination	cjr03440	AAW34497	160	No	Yes
35	CJE1845	RecA	K03553	Homologous recombination	cjr03440	AAW36267	343	No	Yes
36	CJE0001	chromosomal replication initiator protein DnaA	K02313	Two-component system	cjr02020	AAW34498	440	No	Yes
37	CJE0198	undecaprenol kinase, putative	K06153	Peptidoglycan biosynthesis	cjr00550	AAW34792	267	No	Yes
38	CJE0406	Conserved hypothetical ProteinTIGR00023	K08591	Glycerolipid metabolism	cjr00561	AAW34995.1	202	No	Yes

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