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3. Pathway-based targets
3.2. Characteristic features of pathway-based drug targets
No. |
KEGG ID |
Protein Name |
KO Number |
Pathway |
Pathway ID |
NCBI Protein ID |
Length (a.a.) |
Chokepoint Enzyme |
Virulence Factor |
1 |
CJE1596 |
holo-(acyl-carrier-protein) synthase |
K00997
|
Pantothenate and CoA biosynthesis |
cjr00770 |
AAW36029 |
115 |
Yes |
No |
2 |
CJE1405 |
N-acetylmuramoyl-L-alanine amidase |
K01448
|
Cationic antimicrobial peptide resistance |
cjr01503 |
AAW35724 |
659 |
Yes |
No
|
3 |
CJE1810 |
DNA primase |
K02316 |
DNA replication |
cjr03030 |
AAW36232 |
605 |
No |
Yes |
4 |
CJE1654 |
ATP-dependent DNA helicase, UvrD/REP family |
K03582 |
Homologous recombination |
cjr03440 |
AAW36087 |
921 |
No |
Yes |
5 |
CJE1566 |
non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family |
K02428 |
Purine metabolism |
cjr00230 |
AAW36001 |
200 |
No |
Yes |
6 |
CJE1554 |
Holliday junction DNA helicase RuvB |
K03551 |
Homologous recombination |
cjr03440 |
AAW35989 |
335 |
No |
Yes |
7 |
CJE1486 |
aminotransferase, DegT/DnrJ/EryC1/StrS family |
K15895 |
Amino sugar and nucleotide sugar metabolism |
cjr00520 |
AAW35927 |
376 |
No |
Yes |
8 |
CJE0667 |
replicative DNA helicase |
K02314 |
DNA replication |
cjr03030 |
AAW35822 |
458 |
No |
Yes |
9 |
CJE0684 |
(di)nucleoside polyphosphate hydrolase |
K08311 |
RNA degradation |
cjr03018 |
AAW35806 |
156
|
No |
Yes |
10 |
CJE1406 |
oxidoreductase, 2-nitropropane dioxygenase family |
K00459 |
Nitrogen metabolism |
cjr00910 |
AAW35725 |
363 |
No |
Yes |
11 |
CJE1401 |
quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit |
K03620 |
Two-component system |
cjr02020 |
AAW35720 |
238 |
No |
Yes |
12 |
CJE1382 |
excinuclease ABC, C subunit |
K03703 |
Nucleotide excision repair |
cjr03420 |
AAW35702 |
600 |
No |
Yes |
13 |
CJE1343 |
HD/HDIG/KH domain protein |
K18682 |
RNA degradation |
cjr03018 |
AAW35664 |
517 |
No |
Yes |
14 |
CJE1292 |
transcription termination factor Rho |
K03628 |
RNA degradation |
cjr03018 |
AAW35614 |
432 |
No |
Yes |
15 |
CJE1264 |
general glycosylation pathway protein |
K15910 |
Amino sugar and nucleotide sugar metabolism |
cjr00520 |
AAW35586 |
386 |
No |
Yes |
16 |
CJE1228 |
transcription-repair coupling factor |
K03723 |
Nucleotide excision repair |
cjr03420 |
AAW35550 |
978 |
No |
Yes |
17 |
CJE1196 |
DNA mismatch repair protein |
K07456 |
Mismatch repair |
cjr03430 |
AAW35521 |
735 |
No |
Yes |
18 |
CJE1067 |
hippurate hydrolase |
K01451 |
Phenylalanine metabolism |
cjr00360 |
AAW35395 |
383 |
No |
Yes |
19 |
CJE0993 |
thioesterase family protein |
K10806 |
Biosynthesis of unsaturated fatty acids |
cjr01040 |
AAW35326 |
137 |
No |
Yes |
20 |
CJE0966 |
flagellin family protein |
K02397 |
Flagellar assembly |
cjr02040 |
AAW35299 |
750 |
No |
Yes |
21 |
CJE0951 |
thiol:disulfide interchange protein DsbA |
K03673 |
Cationic antimicrobial peptide (CAMP) resistance |
cjr01503 |
AAW35288 |
220 |
No |
Yes |
22 |
CJE0949 |
para-aminobenzoate synthase glutamine amidotransferase, component I |
K03342 |
Folate biosynthesis |
cjr00790 |
AAW35286 |
594 |
No |
Yes |
23 |
CJE0943 |
signal peptidase I |
K03100 |
Protein export |
cjr03060 |
AAW35280 |
282 |
No |
Yes |
24 |
CJE0892 |
integral membrane protein MviN |
K03980 |
Peptidoglycan biosynthesis |
cjr00550 |
AAW35229 |
483 |
No |
Yes |
25 |
CJE0890 |
Holliday junction DNA helicase RuvA |
K03550 |
Homologous recombination |
cjr03440 |
AAW35227 |
183 |
No |
Yes |
26 |
CJE0860 |
flagellar basal-body P-ring formation protein FlgA, putative |
K02386 |
Flagellar assembly |
cjr02040 |
AAW35197 |
220 |
No |
Yes |
27 |
CJE0514 |
ATP-dependent DNA helicase RecG |
K03655 |
Homologous recombination |
cjr03440 |
AAW35101 |
607 |
No |
Yes |
28 |
CJE0410 |
lipoprotein signal peptidase |
K03101 |
Protein export |
cjr03060 |
AAW34999 |
156 |
No |
Yes |
29 |
CJE0402 |
phosphatase, Ppx/GppA family |
K01524 |
Purine metabolism |
cjr00230 |
AAW34991 |
486 |
No |
Yes |
30 |
CJE0390 |
excinuclease ABC, A subunit |
K03701 |
Nucleotide excision repair |
cjr03420 |
AAW34979 |
940 |
No |
Yes |
31 |
CJE0288 |
carbonic anhydrase |
K01673 |
Nitrogen metabolism |
cjr00910 |
AAW34880 |
211 |
No |
Yes |
32 |
CJE0782 |
primosomal protein N' |
K04066 |
Homologous recombination |
cjr03440 |
AAW34570 |
617 |
No |
Yes |
33 |
CJE0771 |
RNA polymerase sigma-54 factor |
K03092 |
Two-component system |
cjr02020 |
AAW34562 |
416 |
No |
Yes |
34 |
CJE1897 |
crossover junction endodeoxyribonucleaseRuvC |
K01159 |
Homologous recombination |
cjr03440 |
AAW34497 |
160 |
No |
Yes |
35 |
CJE1845 |
RecA |
K03553 |
Homologous recombination |
cjr03440 |
AAW36267 |
343 |
No |
Yes |
36 |
CJE0001 |
chromosomal replication initiator protein DnaA |
K02313 |
Two-component system |
cjr02020 |
AAW34498 |
440 |
No |
Yes |
37 |
CJE0198 |
undecaprenol kinase, putative |
K06153 |
Peptidoglycan biosynthesis |
cjr00550 |
AAW34792 |
267 |
No |
Yes |
38 |
CJE0406 |
Conserved hypothetical ProteinTIGR00023 |
K08591 |
Glycerolipid metabolism |
cjr00561 |
AAW34995.1 |
202 |
No |
Yes |