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Therapeutic targets
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1. Potential therapeutic targets
2. Druggability of drug targets
3. Pathway-based targets
3.1. List of pathway-based drug targets
3.2. Characteristic features of pathway-based drug targets
4.1.1 T-Cell epitopes
4.2 B-Cell epitopes
5. Experimental structures
| No. | Protein ID | Protein Name |
| 1 | sp|Q5HT08|ACPS_CAMJR | Holo-[acyl-carrier-protein] synthase |
| 2 | gi|57166945|gb|AAW35724.1| | N-acetylmuramoyl-L-alanine amidase |
| 3 | gi|57167453|gb|AAW36232.1| | DNA primase |
| 4 | gi|57167308|gb|AAW36087.1| | ATP-dependent DNA helicase, UvrD/REP family |
| 5 | gi|57167222|gb|AAW36001.1| | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family |
| 6 | gi|57167210|gb|AAW35989.1| | Holliday junction DNA helicase RuvB |
| 7 | gi|57167148|gb|AAW35927.1| | aminotransferase, DegT/DnrJ/EryC1/StrS family |
| 8 | gi|57167043|gb|AAW35822.1| | replicative DNA helicase |
| 9 | gi|57167027|gb|AAW35806.1| | (di)nucleoside polyphosphate hydrolase |
| 10 | gi|57166946|gb|AAW35725.1| | oxidoreductase, 2-nitropropane dioxygenase family |
| 11 | gi|57166941|gb|AAW35720.1| | quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit |
| 12 | gi|57166923|gb|AAW35702.1| | excinuclease ABC, C subunit |
| 13 | gi|57166885|gb|AAW35664.1| | HD/HDIG/KH domain protein |
| 14 | gi|57166835|gb|AAW35614.1| | transcription termination factor Rho |
| 15 | gi|57166807|gb|AAW35586.1| | general glycosylation pathway protein |
| 16 | gi|57166771|gb|AAW35550.1| | transcription-repair coupling factor |
| 17 | gi|57166742|gb|AAW35521.1| | DNA mismatch repair protein |
| 18 | gi|57166616|gb|AAW35395.1| | hippurate hydrolase |
| 19 | gi|57166547|gb|AAW35326.1| | thioesterase family protein |
| 20 | gi|57166520|gb|AAW35299.1| | flagellin family protein |
| 21 | gi|57166509|gb|AAW35288.1| | thiol:disulfide interchange protein DsbA |
| 22 | gi|57166507|gb|AAW35286.1| | para-aminobenzoate synthase glutamine amidotransferase, component I |
| 23 | gi|57166501|gb|AAW35280.1| | signal peptidase I |
| 24 | gi|57166450|gb|AAW35229.1| | integral membrane protein MviN |
| 25 | gi|57166448|gb|AAW35227.1| | Holliday junction DNA helicase RuvA |
| 26 | gi|57166418|gb|AAW35197.1| | flagellar basal-body P-ring formation protein FlgA, putative |
| 27 | gi|57166322|gb|AAW35101.1| | ATP-dependent DNA helicase RecG |
| 28 | gi|57166220|gb|AAW34999.1| | lipoprotein signal peptidase |
| 29 | gi|57166212|gb|AAW34991.1| | phosphatase, Ppx/GppA family |
| 30 | gi|57166200|gb|AAW34979.1| | excinuclease ABC, A subunit |
| 31 | gi|57166101|gb|AAW34880.1| | carbonic anhydrase |
| 32 | gi|57165791|gb|AAW34570.1| | primosomal protein N' |
| 33 | gi|57165783|gb|AAW34562.1| | RNA polymerase sigma-54 factor |
| 34 | gi|57165718|gb|AAW34497.1| | crossover junction endodeoxyribonuclease RuvC |
| 35 | gi|76363322|sp|Q5HSC0.1| | Protein RecA |
| 36 | gi|71151795|sp|Q5HXF5.1| | Chromosomal replication initiator protein DnaA |
| 37 | gi|68566122|sp|Q5HWW4.1| | Undecaprenyl-diphosphatase |
| 38 | gi|57166216|gb|AAW34995.1| | conserved hypothetical protein TIGR00023 |
2. Druggability of drug targets Back to therapeutic targets
| No. | Protein | E Value | Drug name |
| 1 | sp|Q5HT08|ACPS_CAMJR | 1.30033e-11 | Coenzyme A |
| 1,4-Dithiothreitol | |||
| 2 | gi|57166945|gb|AAW35724.1| | Novel | |
| 3 | gi|57167453|gb|AAW36232.1| | Novel | |
| 4 | gi|57167308|gb|AAW36087.1| | Novel | |
| 5 | gi|57167222|gb|AAW36001.1| | Novel | |
| 6 | gi|57167210|gb|AAW35989.1| | 4.143e-106 | Adenine |
| 7 | gi|57167148|gb|AAW35927.1| | 2.38885e-45 | Pyridoxamine-5'-Phosphate |
| Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate | |||
| 8 | gi|57167043|gb|AAW35822.1| | Novel | |
| 9 | gi|57167027|gb|AAW35806.1| | Novel | |
| 10 | gi|57166946|gb|AAW35725.1| | Novel | |
| 11 | gi|57166941|gb|AAW35720.1| | Novel | |
| 12 | gi|57166923|gb|AAW35702.1| | Novel | |
| 13 | gi|57166885|gb|AAW35664.1| | Novel | |
| 14 | gi|57166835|gb|AAW35614.1| | Novel | |
| 15 | gi|57166807|gb|AAW35586.1| | Experimental | |
| 16 | gi|57166771|gb|AAW35550.1| | Novel | |
| 17 | gi|57166742|gb|AAW35521.1| | Novel | |
| 18 | gi|57166616|gb|AAW35395.1| | Novel | |
| 19 | gi|57166547|gb|AAW35326.1| | 2.39426e-33 | Coenzyme A |
| 1.22552e-15 | Coenzyme A | ||
| 2.85073e-13 | Coenzyme A | ||
| 20 | gi|57166520|gb|AAW35299.1| | Novel | |
| 21 | gi|57166509|gb|AAW35288.1| | Experimental | |
| 22 | gi|57166507|gb|AAW35286.1| | Experimental | |
| 23 | gi|57166501|gb|AAW35280.1| | Experimental | |
| 24 | gi|57166450|gb|AAW35229.1| | Novel | |
| 25 | gi|57166448|gb|AAW35227.1| | Novel | |
| 26 | gi|57166418|gb|AAW35197.1| | Novel | |
| 27 | gi|57166322|gb|AAW35101.1| | Novel | |
| 28 | gi|57166220|gb|AAW34999.1| | Novel | |
| 29 | gi|57166212|gb|AAW34991.1| | Experimental | |
| 30 | gi|57166200|gb|AAW34979.1| | 4.69336e-07 | Colchicine |
| Silodosin | |||
| Etravirine | |||
| 1.0096e-06 | Doxorubicin | ||
| 2.34716e-06 | Gramicidin D | ||
| Cyclosporine | |||
| Adenosine triphosphate | |||
| Pravastatin | |||
| Fluvoxamine | |||
| Fluconazole | |||
| Erythromycin | |||
| Erythromycin | |||
| Caffeine | |||
| Reserpine | |||
| 31 | gi|57166101|gb|AAW34880.1| | Novel | |
| 32 | gi|57165791|gb|AAW34570.1| | Novel | |
| 33 | gi|57165783|gb|AAW34562.1| | Novel | |
| 34 | gi|57165718|gb|AAW34497.1| | Novel | |
| 35 | gi|76363322|sp|Q5HSC0.1| | Experimental | |
| 36 | gi|71151795|sp|Q5HXF5.1| | Novel | |
| 37 | gi|68566122|sp|Q5HWW4.1| | Novel | |
| 38 | gi|57166216|gb|AAW34995.1| | Novel |
3. Pathway-based targets Back to therapeutic targets
3.1. List of pathway-based drug targets
|
No. |
KEGG ID |
Protein Name |
KO Number |
Pathway |
Pathway ID |
NCBI Protein ID |
Length (a.a.) |
Chokepoint Enzyme |
Virulence Factor |
|
1 |
CJE1596 |
holo-(acyl-carrier-protein) synthase |
K00997
|
Pantothenate and CoA biosynthesis |
cjr00770 |
AAW36029 |
115 |
Yes |
No |
|
2 |
CJE1405 |
N-acetylmuramoyl-L-alanine amidase |
K01448
|
Cationic antimicrobial peptide resistance |
cjr01503 |
AAW35724 |
659 |
Yes |
No
|
|
3 |
CJE1810 |
DNA primase |
K02316 |
DNA replication |
cjr03030 |
AAW36232 |
605 |
No |
Yes |
|
4 |
CJE1654 |
ATP-dependent DNA helicase, UvrD/REP family |
K03582 |
Homologous recombination |
cjr03440 |
AAW36087 |
921 |
No |
Yes |
|
5 |
CJE1566 |
non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family |
K02428 |
Purine metabolism |
cjr00230 |
AAW36001 |
200 |
No |
Yes |
|
6 |
CJE1554 |
Holliday junction DNA helicase RuvB |
K03551 |
Homologous recombination |
cjr03440 |
AAW35989 |
335 |
No |
Yes |
|
7 |
CJE1486 |
aminotransferase, DegT/DnrJ/EryC1/StrS family |
K15895 |
Amino sugar and nucleotide sugar metabolism |
cjr00520 |
AAW35927 |
376 |
No |
Yes |
|
8 |
CJE0667 |
replicative DNA helicase |
K02314 |
DNA replication |
cjr03030 |
AAW35822 |
458 |
No |
Yes |
|
9 |
CJE0684 |
(di)nucleoside polyphosphate hydrolase |
K08311 |
RNA degradation |
cjr03018 |
AAW35806 |
156
|
No |
Yes |
|
10 |
CJE1406 |
oxidoreductase, 2-nitropropane dioxygenase family |
K00459 |
Nitrogen metabolism |
cjr00910 |
AAW35725 |
363 |
No |
Yes |
|
11 |
CJE1401 |
quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit |
K03620 |
Two-component system |
cjr02020 |
AAW35720 |
238 |
No |
Yes |
|
12 |
CJE1382 |
excinuclease ABC, C subunit |
K03703 |
Nucleotide excision repair |
cjr03420 |
AAW35702 |
600 |
No |
Yes |
|
13 |
CJE1343 |
HD/HDIG/KH domain protein |
K18682 |
RNA degradation |
cjr03018 |
AAW35664 |
517 |
No |
Yes |
|
14 |
CJE1292 |
transcription termination factor Rho |
K03628 |
RNA degradation |
cjr03018 |
AAW35614 |
432 |
No |
Yes |
|
15 |
CJE1264 |
general glycosylation pathway protein |
K15910 |
Amino sugar and nucleotide sugar metabolism |
cjr00520 |
AAW35586 |
386 |
No |
Yes |
|
16 |
CJE1228 |
transcription-repair coupling factor |
K03723 |
Nucleotide excision repair |
cjr03420 |
AAW35550 |
978 |
No |
Yes |
|
17 |
CJE1196 |
DNA mismatch repair protein |
K07456 |
Mismatch repair |
cjr03430 |
AAW35521 |
735 |
No |
Yes |
|
18 |
CJE1067 |
hippurate hydrolase |
K01451 |
Phenylalanine metabolism |
cjr00360 |
AAW35395 |
383 |
No |
Yes |
|
19 |
CJE0993 |
thioesterase family protein |
K10806 |
Biosynthesis of unsaturated fatty acids |
cjr01040 |
AAW35326 |
137 |
No |
Yes |
|
20 |
CJE0966 |
flagellin family protein |
K02397 |
Flagellar assembly |
cjr02040 |
AAW35299 |
750 |
No |
Yes |
|
21 |
CJE0951 |
thiol:disulfide interchange protein DsbA |
K03673 |
Cationic antimicrobial peptide (CAMP) resistance |
cjr01503 |
AAW35288 |
220 |
No |
Yes |
|
22 |
CJE0949 |
para-aminobenzoate synthase glutamine amidotransferase, component I |
K03342 |
Folate biosynthesis |
cjr00790 |
AAW35286 |
594 |
No |
Yes |
|
23 |
CJE0943 |
signal peptidase I |
K03100 |
Protein export |
cjr03060 |
AAW35280 |
282 |
No |
Yes |
|
24 |
CJE0892 |
integral membrane protein MviN |
K03980 |
Peptidoglycan biosynthesis |
cjr00550 |
AAW35229 |
483 |
No |
Yes |
|
25 |
CJE0890 |
Holliday junction DNA helicase RuvA |
K03550 |
Homologous recombination |
cjr03440 |
AAW35227 |
183 |
No |
Yes |
|
26 |
CJE0860 |
flagellar basal-body P-ring formation protein FlgA, putative |
K02386 |
Flagellar assembly |
cjr02040 |
AAW35197 |
220 |
No |
Yes |
|
27 |
CJE0514 |
ATP-dependent DNA helicase RecG |
K03655 |
Homologous recombination |
cjr03440 |
AAW35101 |
607 |
No |
Yes |
|
28 |
CJE0410 |
lipoprotein signal peptidase |
K03101 |
Protein export |
cjr03060 |
AAW34999 |
156 |
No |
Yes |
|
29 |
CJE0402 |
phosphatase, Ppx/GppA family |
K01524 |
Purine metabolism |
cjr00230 |
AAW34991 |
486 |
No |
Yes |
|
30 |
CJE0390 |
excinuclease ABC, A subunit |
K03701 |
Nucleotide excision repair |
cjr03420 |
AAW34979 |
940 |
No |
Yes |
|
31 |
CJE0288 |
carbonic anhydrase |
K01673 |
Nitrogen metabolism |
cjr00910 |
AAW34880 |
211 |
No |
Yes |
|
32 |
CJE0782 |
primosomal protein N' |
K04066 |
Homologous recombination |
cjr03440 |
AAW34570 |
617 |
No |
Yes |
|
33 |
CJE0771 |
RNA polymerase sigma-54 factor |
K03092 |
Two-component system |
cjr02020 |
AAW34562 |
416 |
No |
Yes |
|
34 |
CJE1897 |
crossover junction endodeoxyribonucleaseRuvC |
K01159 |
Homologous recombination |
cjr03440 |
AAW34497 |
160 |
No |
Yes |
|
35 |
CJE1845 |
RecA |
K03553 |
Homologous recombination |
cjr03440 |
AAW36267 |
343 |
No |
Yes |
|
36 |
CJE0001 |
chromosomal replication initiator protein DnaA |
K02313 |
Two-component system |
cjr02020 |
AAW34498 |
440 |
No |
Yes |
|
37 |
CJE0198 |
undecaprenol kinase, putative |
K06153 |
Peptidoglycan biosynthesis |
cjr00550 |
AAW34792 |
267 |
No |
Yes |
|
38 |
CJE0406 |
Conserved hypothetical ProteinTIGR00023 |
K08591 |
Glycerolipid metabolism |
cjr00561 |
AAW34995.1 |
202 |
No |
Yes |
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