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সর্ব-শেষ হাল-নাগাদ: ২১st অক্টোবর ২০১৬
Essential Proteins Home
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1. Retrieval of Survival Proteins
1.1 Chokepoint enzymes
1.2 Plasmid proteins
1.3 Virulence factor [Download as .xlsx file]
1.4 Antibiotic resistance
1.4.1 Antibiotic Resistance genes
1.4.2 Antibiotic Resistance proteins
2. Screened essential survival targets by DEG [Download as .xlsx file]
3. Essential proteins with metabolic pathway
4. List of essential drug targets
1. Retrieval of Survival Proteins:1.1 Chokepoint enzymes including 236 consuming side and 260 producing side (Download .xlsx file)
Showing 1-212 of 260 Reactions that are chokepoints on the consuming side see also: 201-260
| No. | Enzyme entry | Accepted name | Reaction catalyzed |
| 1 | EC 4.1.3.30 | Methylisocitrate lyase | (2R,3S)-2-methylisocitrate → succinate + pyruvate |
| 2 | EC 4.2.1.99 | 2-methylisocitrate dehydratase | (2R,3S)-2-methylisocitrate ← cis-2-methylaconitate + H2O |
| (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O → (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran | |||
| (2S)-2-amino-3-oxo-4-phosphonooxybutanoate + H+ → 3-amino-1-hydroxyacetone 1-phosphate + CO2 | |||
| (2S)-2-isopropyl-3-oxosuccinate + H+ → 4-methyl-2-oxopentanoate + CO2 | |||
| 3 | EC 4.2.1.79 | 2-methylcitrate dehydratase | (2S,3S)-2-methylcitrate → cis-2-methylaconitate + H2O |
| (2S,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O → (2S,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran | |||
| (2Z)-2-aminobut-2-enoate → 2-iminobutanoate | |||
| 4 | EC 6.5.1.1 | DNA ligase (ATP) | (deoxynucleotides)(m) + ATP + (deoxynucleotides)n → AMP + (deoxynucleotides)(n+m) + diphosphate |
| 5 | EC 2.4.-.- | lipopolysaccharide heptosyltransferase I | (KDO)2-lipid A + ADP-L-glycero-β-D-manno-heptose → heptosyl-Kdo2-lipid A + ADP + H+ |
| 6 | EC 4.2.1.9 | Dihydroxy-acid dehydratase | (R)-2,3-dihydroxy-3-methylbutanoate → 3-methyl-2-oxobutanoate + H2O |
| 7 | EC 4.2.1.9 | Dihydroxy-acid dehydratase | (R)-2,3-dihydroxy-3-methylpentanoate → (S)-3-methyl-2-oxopentanoate + H2O |
| 8 | EC 1.1.1.86 | Ketol-acid reductoisomerase (NADP(+)) | (R)-2,3-dihydroxy-3-methylpentanoate + NADP+ ← (S)-2-aceto-2-hydroxybutanoate + NADPH + H+ |
| 9 | EC 1.1.1.169 | 2-dehydropantoate 2-reductase | (R)-pantoate + NADP+ ← 2-dehydropantoate + NADPH + H+ |
| 10 | EC 2.7.1.33 | Pantothenate kinase | (R)-pantothenate + ATP → D-4'-phosphopantothenate + ADP + H+ |
| 11 | EC 3.5.2.3 | Dihydroorotase | (S)-dihydroorotate + H2O ← N-carbamoyl-L-aspartate + H+ |
| (S)-lactate + an unknown oxidized electron acceptor → pyruvate + an unknown reduced electron acceptor | |||
| 12 | EC 2.7.1.170 | Anhydro-N-acetylmuramic acid kinase | 1,6-anhydro-N-acetyl-β-muramate + ATP + H2O → N-acetyl-β-muramate 6-phosphate + ADP + H+ |
| 13 | EC 5.3.1.16 | 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase | 1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide → phosphoribulosylformimino-AICAR-P |
| 14 | EC 3.5.4.19 | Phosphoribosyl-AMP cyclohydrolase | 1-(5-phospho-β-D-ribosyl)-AMP + H2O → 1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide |
| 15 | EC 3.6.1.31 | Phosphoribosyl-ATP diphosphatase | 1-(5-phospho-β-D-ribosyl)-ATP + H2O → 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate + 2 H+ |
| 16 | EC 4.1.1.48 | Indole-3-glycerol-phosphate synthase | 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H+ → (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O |
| 17 | EC 2.8.1.10 | Thiazole synthase | 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + a thiocarboxy-[ThiS-Protein] → 2-[(2R,5Z)-(2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + a ThiS sulfur-carrier protein + 2 H2O |
| 18 | EC 1.1.1.101 | Acylglycerone-phosphate reductase | 1-oleoyl-2-lyso-glycerone phosphate + NADPH + H+ → 1-oleyl-2-lyso-phosphatidate + NADP+ |
| 19 | EC 2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase | 1-oleyl-2-lyso-phosphatidate + oleoyl-CoA → 1-18:1-2-18:1-phosphatidate + coenzyme A |
| 20 | EC 3.1.3.25 | Inositol-phosphate phosphatase | 1D-myo-inositol 3-monophosphate + H2O → myo-inositol + phosphate |
| 21 | EC 4.2.1.24 | Porphobilinogen synthase | 2 5-amino-levulinate → porphobilinogen + H+ + 2 H2O |
| 22 | EC 2.5.1.9 | Riboflavin synthase | 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ → 5-amino-6-(D-ribitylamino)uracil + riboflavin |
| 2 a biotinylated [BCCP monomer] → a biotinylated [BCCP dimer] | |||
| 23 | EC 3.4.16.4 | Serine-type D-Ala-D-Ala carboxypeptidase | 2 a peptidoglycan dimer (meso-diaminopimelate containing) → a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) + D-alanine |
| 24 | EC 6.3.2.4 | D-alanine--D-alanine ligase | 2 D-alanine + ATP → D-alanyl-D-alanine + ADP + phosphate + H+ |
| 25 | EC 2.4.1.- | 2.4.1 -- Hexosyltransferases | 2 decaprenyl-pyrophosphoryl-(N-acetylglucosamine)-N-acetylmuramyl-(pentapeptide) → a peptidoglycan dimer (mycobacteria) + ω, mono-trans,octa-cis-decaprenyl diphosphate + H+ |
| 2 glutathione + an oxidized glutaredoxin → glutathione disulfide + a reduced glutaredoxin | |||
| 26 | EC 1.15.1.1 | Superoxide dismutase | 2 superoxide + 2 H+ → hydrogen peroxide + oxygen |
| 27 | EC 2.4.1.182 | Lipid-A-disaccharide synthase | 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate + UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-α-D-glucosamine → lipid A disaccharide + UDP + H+ |
| 28 | EC 3.5.4.26 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase | 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O → 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium |
| 29 | EC 2.5.1.3 | Thiamine-phosphate diphosphorylase | 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2 H+ → thiamin phosphate + CO2 + diphosphate |
| 30 | EC 5.5.1.2 | 3-carboxy-cis,cis-muconate cycloisomerase | 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate ← 3-carboxy-cis,cis-muconate + H+ |
| 31 | EC 4.1.1.44 | 4-carboxymuconolactone decarboxylase | 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate + H+ → CO2 + 3-oxoadipate enol lactone |
| 2-iminobutanoate + H+ + H2O → 2-oxobutanoate + ammonium | |||
| 32 | EC 3.5.99.10 | 2-iminobutanoate/2-iminopropanoate deaminase | 2-iminopropanoate + H+ + H2O → pyruvate + ammonium |
| 2-isopropylmaleate + H2O → (2R,3S)-3-isopropylmalate | |||
| 33 | EC 2.6.1.52 | Phosphoserine transaminase | 2-oxo-3-hydroxy-4-phosphobutanoate + L-glutamate → 4-phospho-hydroxy-L-threonine + 2-oxoglutarate |
| 34 | EC 2.7.1.24 | Dephospho-CoA kinase | 3'-dephospho-CoA + ATP → ADP + coenzyme A + H+ |
| 3-dehydrocholate + NADH + H+ → isocholate + NAD+ | |||
| 35 | EC 4.2.1.10 | 3-dehydroquinate dehydratase | 3-dehydroquinate → 3-dehydroshikimate + H2O |
| 36 | EC 4.2.3.4 | 3-dehydroquinate synthase | 3-deoxy-D-arabino-heptulosonate-7-phosphate → 3-dehydroquinate + phosphate |
| 37 | EC 2.7.7.38 | 3-deoxy-manno-octulosonate cytidylyltransferase | 3-deoxy-D-manno-octulosonate + CTP → CMP-3-deoxy-D-manno-octulosonate + diphosphate |
| 38 | EC 3.1.3.45 | 3-deoxy-manno-octulosonate-8-phosphatase | 3-deoxy-D-manno-octulosonate 8-phosphate + H2O → 3-deoxy-D-manno-octulosonate + phosphate |
| 39 | EC 3.1.1.24 | 3-oxoadipate enol-lactonase | 3-oxoadipate enol lactone + H2O → 3-oxoadipate + H+ |
| 40 | EC 2.6.1.52 | Phosphoserine transaminase | 3-phospho-L-serine + 2-oxoglutarate ← L-glutamate + 3-phospho-hydroxypyruvate |
| 41 | EC 3.1.3.3 | Phosphoserine phosphatase | 3-phospho-L-serine + H2O → L-serine + phosphate |
| 42 | EC 1.1.1.238 | 12-beta-hydroxysteroid dehydrogenase | 3α,7α,12β-trihydroxy-5β-cholan-24-oate + NADP+← 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate + NADPH + H+ |
| 43 | EC 2.5.1.61 | Hydroxymethylbilane synthase | 4 porphobilinogen + H2O → 4 ammonium + hydroxymethylbilane |
| 44 | EC 2.7.7.3 | Pantetheine-phosphate adenylyltransferase | 4'-phosphopantetheine + ATP + H+→ 3'-dephospho-CoA + diphosphate |
| 45 | EC 2.7.4.7 | Phosphomethylpyrimidine kinase | 4-amino-2-methyl-5-phosphomethylpyrimidine + ATP → 4-amino-2-methyl-5-diphosphomethylpyrimidine + ADP |
| 46 | EC 4.1.3.38 | Aminodeoxychorismate lyase | -amino-4-deoxychorismate → 4-aminobenzoate + pyruvate + H+ |
| 47 | EC 2.5.1.15 | Dihydropteroate synthase | 4-aminobenzoate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate → 7,8-dihydropteroate + diphosphate |
| 48 | EC 3.7.1.2 | Fumarylacetoacetase | 4-fumaryl-acetoacetate + H2O → fumarate + acetoacetate + H+ |
| 49 | EC 5.2.1.2 | Maleylacetoacetate isomerase | 4-maleyl-acetoacetate → 4-fumaryl-acetoacetate |
| 50 | EC 2.5.1.3 | Thiamine-phosphate diphosphorylase | 4-methyl-5-(2-phosphonooxyethyl)thiazole + 4-amino-2-methyl-5-diphosphomethylpyrimidine + H+→ thiamin phosphate + diphosphate |
| 51 | EC 4.3.2.2 | Adenylosuccinate lyase | 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole → fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
| 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O → 5-amino-6-(D-ribitylamino)uracil + phosphate | |||
| 52 | EC 1.1.1.193 | 5-amino-6-(5-phosphoribosylamino)uracil reductase | 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+← 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+ |
| 53 | EC 2.5.1.78 | 6,7-dimethyl-8-ribityllumazine synthase | 5-amino-6-(D-ribitylamino)uracil + 1-deoxy-L-glycero-tetrulose 4-phosphate → 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + H++ 2 H2O |
| 54 | EC 4.2.3.5 | Chorismate synthase | 5-enolpyruvyl-shikimate 3-phosphate → chorismate + phosphate |
| 55 | EC 6.3.4.13 | Phosphoribosylamine--glycine ligase | 5-phospho-β-D-ribosylamine + ATP + glycine → ADP + N1-(5-phospho-β-D-ribosyl)glycinamide + phosphate + H+ |
| 56 | EC 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | 6-hydroxymethyl-7,8-dihydropterin + ATP → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + H+ |
| 57 | EC 4.1.2.25 | Dihydroneopterin aldolase | 7,8-dihydroneopterin → glycolaldehyde + 6-hydroxymethyl-7,8-dihydropterin |
| 58 | EC 3.6.1.- | 7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate | |
| 59 | EC 3.6.1.- | 7,8-dihydroneopterin triphosphate + H2O → 7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ | |
| 60 | EC 1.1.1.201 | 7-beta-hydroxysteroid dehydrogenase (NADP(+)) | 7-epicholate + NADP+← 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADPH + H+ |
| 61 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | a (3R)-3-hydroxy cisΔ7-tetradecenoyl-[acp] → a trans-Δ3-cis-Δ7-tetradecenoyl-[acp] + H2O |
| 62 | EC 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | a (3R)-3-hydroxy cisΔ7-tetradecenoyl-[acp] + NADP+← a 3-oxo-cis-Δ7-tetradecenoyl-[acp] + NADPH + H+ |
| 63 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | a (3R)-3-hydroxy cisΔ9-hexadecenoyl-[acp] → a trans-Δ3-cis-Δ9-hexadecenoyl-[acp] + H2O |
| 64 | EC 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | a (3R)-3-hydroxy cisΔ9-hexadecenoyl-[acp] + NADP+← a 3-oxo-cis-Δ9-hexadecenoyl-[acp] + NADPH + H+ |
| 65 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxyacyl-[acyl-carrier protein] → a trans-2-enoyl-[acyl-carrier protein] + H2O |
| 66 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 67 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 68 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxybutanoyl-[acp] → a crotonyl-[acp] + H2O |
| 69 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 70 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 71 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxydecanoyl-[acp] → a trans-Δ2-decenoyl-[acp] + H2O |
| 72 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 73 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 74 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxydodecanoyl-[acp] → a transdodec-2-enoyl-[acp] + H2O |
| 75 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 76 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 77 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxyhexanoyl-[acp] → a transhex-2-enoyl-[acp] + H2O |
| 78 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 79 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 80 | EC 2.3.1.191 | UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase | a (3R)-3-hydroxymyristoyl-[acp] + UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine → UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-α-D-glucosamine + a holo-[acyl-carrier protein] + H+ |
| 81 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxyoctanoyl-[acp] → a transoct-2-enoyl-[acp] + H2O |
| 82 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 83 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 84 | EC 2.3.1.85 | Fatty-acid synthase | a (3R)-3-hydroxypalmitoyl-[acp] → a transhexadecenoyl-[acp] + H2O |
| 85 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | |
| 86 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 87 | EC 2.3.1.86 | Fatty-acyl-CoA synthase | a (3R)-3-hydroxystearoyl-[acp] → a trans-octadec-2-enoyl-[acp] + H2O |
| 88 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | |
| 89 | EC 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | a (3R)-hydroxy cisΔ5-dodecenoyl-[acp] → a trans-Δ3-cis-Δ5-dodecenoyl-[acp] + H2O |
| 90 | EC 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | a (3R)-hydroxy cisΔ5-dodecenoyl-[acp] + NADP+← a 3-oxo-cis-Δ5-dodecenoyl-[acp] + NADPH + H+ |
| 91 | EC 2.4.99.17 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | a 7-aminomethyl-7-deazaguanosine34in tRNA + S-adenosyl-L-methionine → an epoxyqueuosine34in tRNA + adenine + L-methionine + 2 H+ |
| 92 | EC 6.3.4.14 | Biotin carboxylase | a biotinylated [BCCP dimer] + hydrogen carbonate + ATP → a carboxylated-biotinylated [BCCP dimer] + ADP + phosphate + H+ |
| a cis-Δ3-decenoyl-[acp] + a malonyl-[acp] + H+→ a 3-oxo-cis-Δ5-dodecenoyl-[acp] + a holo-[acyl-carrier protein] + CO2 | |||
| 93 | EC 2.3.1.41 | Beta-ketoacyl-[acyl-carrier-protein] synthase I | a cis-Δ5-dodecenoyl-[acp] + a malonyl-[acp] + H+→ a 3-oxo-cis-Δ7-tetradecenoyl-[acp] + a holo-[acyl-carrier protein] + CO2 |
| 94 | EC 1.3.1.9 | Enoyl-[acyl-carrier-protein] reductase (NADH) | a cis-Δ5-dodecenoyl-[acp] + NAD+← a trans-Δ3-cis-Δ5-dodecenoyl-[acp] + NADH + H+ |
| 95 | EC 2.3.1.41 | Beta-ketoacyl-[acyl-carrier-protein] synthase I | a cis-Δ7-tetradecenoyl-[acp] + a malonyl-[acp] + H+→ a 3-oxo-cis-Δ9-hexadecenoyl-[acp] + a holo-[acyl-carrier protein] + CO2 |
| 96 | EC 1.3.1.9 | Enoyl-[acyl-carrier-protein] reductase (NADH). | a cis-Δ7-tetradecenoyl-[acp] + NAD+← a trans-Δ3-cis-Δ7-tetradecenoyl-[acp] + NADH + H+ |
| 97 | EC 2.4.2.29 | tRNA-guanine(34) transglycosylase | a guanine34in tRNA + preQ1→ a 7-aminomethyl-7-deazaguanosine34in tRNA + guanine |
| 98 | EC 2.3.1.- | a myristoyl-[acp] + (KDO)2-(lauroyl)-lipid IVA→ (KDO)2-lipid A + a holo-[acyl-carrier protein] | |
| 99 | EC 2.3.1.- | a myristoyl-[acp] + KDO2-(palmitoleoyl)-lipid IVA→ (KDO)2-lipid A, cold adapted + a holo-[acyl-carrier protein] | |
| 100 | EC 1.3.1.9 | Enoyl-[acyl-carrier-protein] reductase (NADH) | a palmitoleoyl-[acp] + NAD+← a trans-Δ3-cis-Δ9-hexadecenoyl-[acp] + NADH + H+ |
| 101 | EC 2.8.1.6 | Biotin synthase | a sulfurated [sulfur carrier] + dethiobiotin + 2 S-adenosyl-L-methionine → an unsulfurated [sulfur carrier] + biotin + 2 5'-deoxyadenosine + 2 L-methionine |
| 102 | EC 2.7.7.73 | Sulfur carrier protein ThiS adenylyltransferase | a ThiS sulfur-carrier protein + ATP → a carboxy-adenylated-[ThiS sulfur-carrier protein] + diphosphate |
| 103 | EC 3.1.26.5 | Ribonuclease P | a tRNA precursor with a 5' extension + H2O → an uncharged tRNA + a single-stranded RNA |
| 104 | EC 6.1.1.5 | Isoleucine--tRNA ligase | a tRNAile+ L-isoleucine + ATP + H+→ an L-isoleucyl-[tRNAile] + AMP + diphosphate |
| 105 | EC 6.1.1.4 | Leucine--tRNA ligase | a tRNAleu+ L-leucine + ATP + H+→ an L-leucyl-[tRNAleu] + AMP + diphosphate |
| 106 | EC 6.1.1.15 | Proline--tRNA ligase | a tRNApro+ L-proline + ATP + H+→ an L-prolyl-[tRNApro] + AMP + diphosphate |
| 107 | EC 6.3.4.15 | Biotin--[acetyl-CoA-carboxylase] ligase | a [biotin-carboxyl-carrier protein monomer] + biotin + ATP → AMP + a biotinylated [BCCP monomer] + diphosphate |
| a [chaperone-ADP]-[disordered-form scaffold protein] complex + ATP → an [Fe-S cluster biosynthesis chaperone]-ATP + a [disordered-form [Fe-S] cluster scaffold protein] + ADP | |||
| a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an apo-iron-sulfur protein → a [chaperone-ADP]-[disordered-form scaffold protein] complex + an [Fe-S cluster biosynthesis co-chaperone] + an [2Fe-2S] cluster protein + phosphate | |||
| a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis chaperone]-ATP → a [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex | |||
| a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+→ a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex | |||
| 108 | EC 2.8.1.7 | Cysteine desulfurase | a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-cysteine → an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex + L-alanine |
| a [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + an [Fe-S cluster biosynthesis co-chaperone] → a [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + L-cystein desulfurase | |||
| 109 | EC 2.1.1.80 | Protein-glutamate O-methyltransferase | a [protein]-α-L-glutamate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + a [protein]-L-glutamate-O5-methyl-ester |
| 110 | EC 3.1.1.61 | Protein-glutamate methylesterase | a [protein]-L-glutamate-O5-methyl-ester + H2O → a [protein]-α-L-glutamate + methanol + H+ |
| 111 | EC 2.3.3.9 | Malate synthase (2-isopropylmalate synthase) | acetyl-CoA + glyoxylate + H2O → (S)-malate + coenzyme A + H+ |
| 112 | EC 3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase | adenosine 3',5'-bisphosphate + H2O → AMP + phosphate |
| 113 | EC 2.7.1.25 | Adenylyl-sulfate kinase | adenosine 5'-phosphosulfate + ATP → phosphoadenosine-5'-phosphosulfate + ADP + H+ |
| 114 | EC 4.3.2.2 | Adenylosuccinate lyase | adenylo-succinate → fumarate + AMP |
| 115 | EC 5.1.3.20 | ADP-glyceromanno-heptose 6-epimerase | ADP-D-glycero-β-D-manno-heptose → ADP-L-glycero-β-D-manno-heptose |
| 116 | EC 2.7.7.13 | Mannose-1-phosphate guanylyltransferase | α-D-mannose 1-phosphate + GTP + H+→ GDP-α-D-mannose + diphosphate |
| 117 | EC 2.5.1.72 | Quinolinate synthase | α-iminosuccinate + dihydroxyacetone phosphate → quinolinate + phosphate + 2 H2O |
| 118 | EC 2.4.99.13 | (Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase | α-Kdo-(2→6)-lipid IVA+ CMP-3-deoxy-D-manno-octulosonate → α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IVA+ CMP + H+ |
| an epoxyqueuosine34in tRNA → a queuosine34in tRNA | |||
| 119 | EC 3.1.3.27 | Phosphatidylglycerophosphatase | an L-1-phosphatidylglycerol-phosphate + H2O → an L-1-phosphatidyl-glycerol + phosphate |
| 120 | EC 4.1.1.65 | Phosphatidylserine decarboxylase | an L-1-phosphatidylserine + H+→ an L-1-phosphatidylethanolamine + CO2 |
| 121 | EC 3.1.1.29 | Aminoacyl-tRNA hydrolase | an L-asparaginyl-[tRNAasn] + H2O → L-asparagine + tRNAasn+ 2 H+ |
| 122 | EC 2.8.1.7 | Cysteine desulfurase | an S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex → a [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex |
| 123 | EC 2.8.1.7 | Cysteine desulfurase | an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex → a [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex |
| an S-sulfanyl-[L-cysteine desulfurase] + a [disordered-form [Fe-S] cluster scaffold protein] → an S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex | |||
| 124 | EC 2.7.2.8 | Acetylglutamate kinase | an [L-2-aminoadipate carrier protein]-L-glutamate + ATP → an [L-2-aminoadipate carrier protein]-L-glutamate 5-phosphate + ADP |
| 125 | EC 1.2.1.38 | N-acetyl-gamma-glutamyl-phosphate reductase | an [L-2-aminoadipate carrier protein]-L-glutamate 5-semialdehyde + NADP++ phosphate ← an [L-2-aminoadipate carrier protein]-L-glutamate 5-phosphate + NADPH + H+ |
| 126 | EC 1.20.4.1 | Arsenate reductase (glutaredoxin) | arsenate + a reduced glutaredoxin + H+→ arsenite + an oxidized glutaredoxin + H2O |
| 127 | EC 3.6.3.16 | Arsenite-transporting ATPase | arsenite[in]+ ATP + H2O → arsenite[out]+ ADP + phosphate + H+ |
| 128 | EC 6.3.3.1 | Phosphoribosylformylglycinamidine cyclo-ligase | ATP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine → ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + phosphate + H+ |
| 129 | EC 6.3.2.6 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate → ADP + 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + phosphate + H+ |
| 130 | EC 2.7.2.1 | Acetate kinase | ATP + acetate ← ADP + acetyl phosphate |
| 131 | EC 6.4.1.2 | Acetyl-CoA carboxylase | ATP + acetyl-CoA + a carboxylated-biotinylated [BCCP dimer] + H2O → malonyl-CoA + a biotinylated [BCCP dimer] + ADP + phosphate + H+ |
| 132 | EC 2.7.4.11 | (Deoxy)adenylate kinase | ATP + dAMP → ADP + dADP |
| 133 | EC 2.7.4.13 | (Deoxy)nucleoside-phosphate kinase | |
| 134 | EC 2.7.4.9 | dTMP kinase | ATP + dTMP → ADP + dTDP |
| 135 | EC 2.7.4.12 | T(2)-induced deoxynucleotide kinase | |
| 136 | EC 2.7.4.13 | (Deoxy)nucleoside-phosphate kinase | |
| 137 | EC 2.7.7.2 | FAD synthetase | ATP + FMN + H+→ FAD + diphosphate |
| 138 | EC 6.3.5.3 | Phosphoribosylformylglycinamidine synthase | ATP + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + H2O → L-glutamate + ADP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + phosphate + H+ |
| 139 | EC 2.7.1.4 | Fructokinase | β-D-fructofuranose + ATP → β-D-fructofuranose 6-phosphate + ADP + H+ |
| 140 | EC 2.7.7.18 | Nicotinate-nucleotide adenylyltransferase | β-nicotinate D-ribonucleotide + ATP + H+→ nicotinate adenine dinucleotide + diphosphate |
| 141 | EC 2.4.2.19 | Nicotinate-nucleotide diphosphorylase (carboxylating) | β-nicotinate D-ribonucleotide + CO2+ diphosphate ← 5-phospho-α-D-ribose 1-diphosphate + quinolinate + 2 H+ |
| 142 | bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase : acnB | cis-aconitate + H2O → D-threo-isocitrate | |
| 143 | EC 2.5.1.55 | 3-deoxy-8-phosphooctulonate synthase | D-arabinose 5-phosphate + phosphoenolpyruvate + H2O → 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate |
| 144 | EC 4.2.1.19 | Imidazoleglycerol-phosphate dehydratase | D-erythro-imidazole-glycerol-phosphate → imidazole acetol-phosphate + H2O |
| 145 | EC 2.3.1.157 | Glucosamine-1-phosphate N-acetyltransferase | D-glucosamine 1-phosphate + acetyl-CoA → N-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H+ |
| 146 | EC 3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | D-glycero-β-D-manno-heptose 1,7-bisphosphate + H2O → D-glycero-β-D-manno-heptose 1-phosphate + phosphate |
| 147 | EC 2.7.7.70 | D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase | D-glycero-β-D-manno-heptose 1-phosphate + ATP + H+→ ADP-D-glycero-β-D-manno-heptose + diphosphate |
| 148 | EC 2.7.1.167 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | D-glycero-D-manno-heptose 7-phosphate + ATP → D-glycero-β-D-manno-heptose 1,7-bisphosphate + ADP + H+ |
| 149 | EC 4.2.1.70 | Pseudouridylate synthase | D-ribose 5-phosphate + uracil ← pseudouridine 5'-phosphate + H2O |
| 150 | EC 3.5.4.13 | dCTP deaminase | dCTP + H++ H2O → ammonium + dUTP |
| 151 | EC 2.4.1.227 | Undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase | decaprenyl-diphospho-N-acetylmuramoyl-pentapeptide + UDP-N-acetyl-α-D-glucosamine → decaprenyl-pyrophosphoryl-(N-acetylglucosamine)-N-acetylmuramyl-(pentapeptide) + UDP + H+ |
| 152 | EC 2.7.4.12 | T(2)-induced deoxynucleotide kinase | dGMP + ATP → dGDP + ADP |
| 153 | EC 2.7.4.13 | (Deoxy)nucleoside-phosphate kinase | |
| 154 | EC 2.7.4.6 | Nucleoside-diphosphate kinase | dTDP + ATP → dTTP + ADP |
| 155 | EC 3.6.1.19 | Nucleoside-triphosphate diphosphatase | dUTP + H2O → dUMP + diphosphate + H+ |
| 156 | EC 3.6.1.23 | dUTP diphosphatase | |
| 157 | EC 1.1.1.290 | 4-phosphoerythronate dehydrogenase | erythronate-4-phosphate + NAD+→ 2-oxo-3-hydroxy-4-phosphobutanoate + NADH + H+ |
| 158 | EC 2.4.-.- | galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate + ADP-L-glycero-β-D-manno-heptose → lipid A-core + ADP + H+ | |
| 159 | EC 4.2.1.47 | GDP-mannose 4,6-dehydratase | GDP-α-D-mannose → GDP-4-dehydro-α-D-rhamnose + H2O |
| 160 | EC 1.1.1.271 | GDP-L-fucose synthase | GDP-β-L-fucose + NADP+← GDP-4-dehydro-α-D-rhamnose + NADPH + H+ |
| 161 | EC 2.7.1.- | glucosyl-(heptosyl)2-Kdo2-lipid A + ATP → glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate + ADP + H+ | |
| 162 | EC 2.4.-.- | glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate + ADP-L-glycero-β-D-manno-heptose → glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate + ADP + H+ | |
| 163 | EC 2.7.1.- | glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate + ATP → glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate + ADP + H+ | |
| 164 | EC 5.4.3.8 | Glutamate-1-semialdehyde 2,1-aminomutase | glutamate-1-semialdehyde → 5-amino-levulinate |
| 165 | EC 1.2.1.70 | Glutamyl-tRNA reductase | glutamate-1-semialdehyde + tRNAGlu+ NADP+← an L-glutamyl-[tRNAGlu] + NADPH |
| glutathioselenol + NADPH + 2 H+→ hydrogen selenide + glutathione + NADP+ | |||
| 166 | EC 2.-.-.- | ADP-heptose--LPS heptosyltransferase II | heptosyl-Kdo2-lipid A + ADP-L-glycero-β-D-manno-heptose → (heptosyl)2-Kdo2-lipid A + ADP + H+ |
| histidinol dehydrogenase | histidinal + NAD++ H2O → L-histidine + NADH + 2 H+ | ||
| 167 | EC 1.13.11.5 | Homogentisate 1,2-dioxygenase | homogentisate + oxygen → 4-maleyl-acetoacetate + H+ |
| hydrogen sulfide + glutathione disulfide → S-sulfanylglutathione + glutathione | |||
| 168 | EC 2.6.1.9 | Histidinol-phosphate transaminase | imidazole acetol-phosphate + L-glutamate → L-histidinol-phosphate + 2-oxoglutarate |
| 169 | EC 3.5.4.10 | IMP cyclohydrolase | IMP + H2O ← 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide |
| 170 | EC 3.4.17.13 | Muramoyltetrapeptide carboxypeptidase | L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2O → L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine |
| 171 | EC 4.3.2.1 | Argininosuccinate lyase | L-arginino-succinate → L-arginine + fumarate |
| 172 | EC 1.2.1.11 | Aspartate-semialdehyde dehydrogenase | L-aspartate-semialdehyde + NADP++ phosphate ← L-aspartyl-4-phosphate + NADPH + H+ |
| 173 | EC 2.5.1.48 | Cystathionine gamma-synthase | L-cysteine + O-succinyl-L-homoserine → succinate + L-cystathionine + H+ |
| 174 | EC 6.3.2.12 | Dihydrofolate synthase | L-glutamate + 7,8-dihydropteroate + ATP → ADP + 7,8-dihydrofolate + phosphate + H+ |
| 175 | EC 6.3.2.- | (no) | L-glutamate + a [LysW protein]-L-glutamate + ATP → an [L-2-aminoadipate carrier protein]-L-glutamate + ADP + phosphate + H+ |
| 176 | EC 1.2.1.41 | Glutamate-5-semialdehyde dehydrogenase | L-glutamate-5-semialdehyde + NADP++ phosphate ← L-glutamate 5-phosphate + NADPH + H+ |
| 177 | EC 6.3.5.7 | Glutaminyl-tRNA synthase (glutamine-hydrolyzing) | L-glutamine + an L-glutamyl-[tRNAGln] + ATP + H2O → L-glutamate + an L-glutaminyl-[tRNAgln] + ADP + phosphate + H+ |
| 178 | EC 3.1.3.15 | Histidinol-phosphatase | L-histidinol-phosphate + H2O → histidinol + phosphate |
| 179 | EC 2.6.1.42 | Branched-chain-amino-acid transaminase | L-isoleucine + 2-oxoglutarate ← L-glutamate + (S)-3-methyl-2-oxopentanoate |
| 180 | EC 4.2.1.122 | Tryptophan synthase (indole-salvaging) | L-serine + indole → L-tryptophan + H2O |
| 181 | EC 2.7.1.130 | Tetraacyldisaccharide 4'-kinase | lipid A disaccharide + ATP → lipid IVA+ ADP + H+ |
| 182 | EC 2.4.99.12 | Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase | lipid IVA+ CMP-3-deoxy-D-manno-octulosonate → α-Kdo-(2→6)-lipid IVA+ CMP + H+ |
| 183 | EC 2.1.1.11 | Magnesium protoporphyrin IX methyltransferase | Mg-protoporphyrin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + magnesium-protoporphyrin IX 13-monomethyl ester |
| 184 | EC 5.3.1.24 | Phosphoribosylanthranilate isomerase | N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate |
| 185 | EC 2.4.2.18 | Anthranilate phosphoribosyltransferase | N-(5-phosphoribosyl)-anthranilate + diphosphate ← anthranilate + 5-phospho-α-D-ribose 1-diphosphate |
| 186 | EC 2.7.7.23 | UDP-N-acetylglucosamine diphosphorylase | N-acetyl-α-D-glucosamine 1-phosphate + UTP + H+→ UDP-N-acetyl-α-D-glucosamine + diphosphate |
| 187 | EC 3.2.1.52 | Beta-N-acetylhexosaminidase | N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + H2O → N-acetyl-β-D-glucosamine + 1,6-anhydro-N-acetyl-β-muramate |
| 188 | EC 4.2.1.126 | N-acetylmuramic acid 6-phosphate etherase | N-acetyl-β-muramate 6-phosphate + H2O → N-acetyl-D-glucosamine 6-phosphate + (R)-lactate |
| 189 | EC 2.7.7.43 | N-acylneuraminate cytidylyltransferase | N-acetyl-β-neuraminate + CTP → CMP-N-acetyl-β-neuraminate + diphosphate |
| 190 | EC 3.5.1.25 | N-acetylglucosamine-6-phosphate deacetylase | N-acetyl-D-glucosamine 6-phosphate + H2O → D-glucosamine 6-phosphate + acetate |
| 191 | EC 2.7.2.8 | Acetylglutamate kinase | N-acetyl-L-glutamate + ATP → N-acetylglutamyl-phosphate + ADP |
| 192 | EC 1.2.1.38 | N-acetyl-gamma-glutamyl-phosphate reductase | N-acetyl-L-glutamate 5-semialdehyde + NADP++ phosphate ← N-acetylglutamyl-phosphate + NADPH + H+ |
| 193 | EC 2.6.1.11 | Acetylornithine transaminase | N-acetyl-L-ornithine + 2-oxoglutarate ← L-glutamate + N-acetyl-L-glutamate 5-semialdehyde |
| 194 | EC 3.5.1.16 | Acetylornithine deacetylase | N-acetyl-L-ornithine + H2O → L-ornithine + acetate |
| 195 | EC 5.4.99.18 | 5-(carboxyamino)imidazole ribonucleotide mutase | N5-carboxyaminoimidazole ribonucleotide → 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate |
| 196 | EC 3.5.1.19 | Nicotinamidase | nicotinamide + H2O → ammonium + nicotinate |
| 197 | EC 6.3.4.21 | Nicotinate phosphoribosyltransferase | nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O → β-nicotinate D-ribonucleotide + ADP + diphosphate + phosphate |
| 198 | EC 2.5.1.49 | O-acetylhomoserine aminocarboxypropyltransferase | O-acetyl-L-homoserine + hydrogen sulfide → L-homocysteine + acetate + H+ |
| 199 | EC 4.2.3.1 | Threonine synthase | O-phospho-L-homoserine + H2O → L-threonine + phosphate |
| 200 | EC 4.1.1.23 | Orotidine-5'-phosphate decarboxylase | orotidine 5'-phosphate + H+→ CO2+ UMP |
| 201 | EC 2.4.2.- | imidazole glycerol phosphate synthase subunit HisF | phosphoribulosylformimino-AICAR-P + L-glutamine → L-glutamate + D-erythro-imidazole-glycerol-phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + H+ |
| 202 | imidazole glycerol phosphate synthase subunit HisH | ||
| 203 | imidazole glycerol phosphate synthase subunit HisH | ||
| 204 | imidazole glycerol phosphate synthase subunit HisF | ||
| 205 | EC 1.3.1.75 | Divinyl chlorophyllide a 8-vinyl-reductase | protochlorophyllide a+ NADP+← 2,4-divinyl protochlorophyllide a+ NADPH + H+ |
| 206 | EC 1.4.3.5 | Pyridoxal 5'-phosphate synthase | pyridoxine 5'-phosphate + oxygen → hydrogen peroxide + pyridoxal 5'-phosphate |
| 207 | EC 4.1.1.36 | Phosphopantothenoylcysteine decarboxylase | R-4'-phosphopantothenoyl-L-cysteine + H+→ 4'-phosphopantetheine + CO2 |
| 208 | EC 2.7.1.26 | Riboflavin kinase | riboflavin + ATP → ADP + FMN + H+ |
| 209 | EC 3.2.2.9 | Adenosylhomocysteine nucleosidase | S-adenosyl-L-homocysteine + H2O → S-ribosyl-L-homocysteine + adenine |
| 210 | EC 4.4.1.21 | S-ribosylhomocysteine lyase | S-ribosyl-L-homocysteine → L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione |
| selenite + 4 glutathione + 2 H+→ selenodiglutathione + glutathione disulfide + 3 H2O | |||
| 211 | EC 1.8.4.9 | Adenylyl-sulfate reductase (glutathione) | selenite + AMP + glutathione disulfide + 3 H+← adenosine 5'-phosphoselenate + 2 glutathione |
| selenodiglutathione + NADPH → glutathioselenol + glutathione + NADP+ | |||
| 212 | EC 2.9.1.1 | L-seryl-tRNA(Sec) selenium transferase | selenophosphate + an L-seryl-[tRNAsec] → an L-selenocysteinyl-[tRNAsec] + phosphate + H+ |
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