কেশব চন্দ্র দাস

মূখ্য বৈজ্ঞানিক কর্মকর্তা ও বিভাগীয় প্রধান

ই-মেইল

keshob@gmail.com, keshob@nib.gov.bd

শিক্ষাগত যোগ্যতা

এম.এসসি (প্রাণরসায়ণ): প্রাণরসায়ন বিভাগ, ঢাকা বিশ্ববিদ্যালয়, ঢাকা, বাংলাদেশ ১৯৯৮

বি.এসসি (প্রাণরসায়ণ): প্রাণরসায়ন বিভাগ, ঢাকা বিশ্ববিদ্যালয়, ঢাকা, বাংলাদেশ ১৯৯৬

পিএইচডি (জীন প্রকৌশল ও জীবপ্রযুক্তি): জীন প্রকৌশল ও জীবপ্রযুক্তি বিভাগ, ঢাকা, বাংলাদেশ (চলমান)।

গবেষণা দক্ষতা

বাংলাদেশের প্রচলিত রোগ সমুহের ক্ষেত্রে নতুন ধরনের জিন এবং জিনগত ভিন্নতার অনুসন্ধান;

রোগসমুহের জৈব মার্কার উন্নয়ন এবং মলিকুলার পদ্ধতিতে সনাক্তকরণ;

বায়োরিসোর্সেস হতে কার্যকরী এন্টিডায়াবেটিক কম্পাউন্ডস এর উন্নয়ন।

বর্তমান গবেষণা ক্ষেত্র/প্রকল্প

বাংলাদেশি জনগোষ্ঠির মধ্যে HMG-CoA reductase জিনের ভিন্নতা (SNP) পর্যবেক্ষণ;

বঙ্গোপসাগর থেকে অর্থনৈতিকভাবে গুরুত্বপূর্ণ সামুদ্রিক উদ্ভিদের অনুসন্ধান;

বাংলাদেশের পার্বত্য অঞ্চল থেকে অর্থনৈতিকভাবে মূল্যবান উদ্ভিদ সনাক্তকরণ এবং বৈশিষ্ট্য নিরূপণ;

বাংলাদেশে প্রাপ্ত SARS-CoV-2 ভাইরাসের জিনোমে মিউটেশন পর্যবেক্ষণ।

কর্ম অভিজ্ঞতা

২০২৩-বর্তমান: প্রধান বৈজ্ঞানিক কর্মকর্তা (চলতি দায়িত্ব), মলিকুলার বায়োটেকনোলজি বিভাগ, ন্যাশনাল ইনস্টিটিউট অব বায়োটেকনোলজি, গণকবাড়ী, আশুলিয়া, সাভার, ঢাকা-১৩৪৯, বাংলাদেশ;

২০১৮-২০২৩: মুখ্য বৈজ্ঞানিক কর্মকর্তা, মলিকুলার বায়োটেকনোলজি বিভাগ, ন্যাশনাল ইনস্টিটিউট অব বায়োটেকনোলজি, গণকবাড়ী, আশুলিয়া, সাভার, ঢাকা-১৩৪৯, বাংলাদেশ;

২০১৩-বর্তমান: ঊর্দ্ধতন বৈজ্ঞানিক কর্মকর্তা, মলিকুলার বায়োটেকনোলজি বিভাগ, ন্যাশনাল ইনস্টিটিউট অব বায়োটেকনোলজি, গণকবাড়ী, আশুলিয়া, সাভার, ঢাকা-১৩৪৯, বাংলাদেশ;

২০০৪-২০১৩: বৈজ্ঞানিক কর্মকর্তা, মলিকুলার বায়োটেকনোলজি বিভাগ, ন্যাশনাল ইনস্টিটিউট অব বায়োটেকনোলজি, গণকবাড়ী, আশুলিয়া, সাভার, ঢাকা-১৩৪৯, বাংলাদেশ;

২০০৩-২০০৪: গবেষণা কর্মকর্তা, মলিকুলার জেনেটিক্স ল্যাবরেটরি, ইন্টারন্যাশনাল সেন্টার ফর ডায়ারিয়াল ডিজিস রিসার্চ, বাংলাদেশ (আইসিডিডিআর,বি), মহাখালী, ঢাকা-১২১২, বাংলাদেশ;

২০০১-২০০৪: রিসার্চ এসোসিয়েট, প্ল্যান্ট বায়োটেকনোলজি ল্যাব, প্রাণরসায়ন বিভাগ, ঢাকা বিশ্ববিদ্যালয়, ঢাকা-১০০০, বাংলাদেশ।

Publications

1. Shamsuzzaman M, Ahsan T, Rahman H, Das KC, Salimullah. Integration of pharmacogenomic and pharmacomicrobiomic data for personalized medicine. Precision Medical Sciences. 2023 Mar;12(1):37-44.

2. Sarker SS, Ahmed KM, Tanny T, Nasrin S, Rahman AM, Das KC, Alam I. Molecular identification and high fidelity micropropagation of shell ginger (Alpinia zerumbet). All Life. 2023 Dec 31;16(1):2169960. https://doi.org/10.1080/26895293.2023.2169960.

3. Bhattacharjee, A., Pranto, S. M. A. M., Ahammad, I., Chowdhury, Z. M., Juliana, F. M., Das, K. C., Keya, C. A., & Salimullah, M. (2023). High risk genetic variants of human insulin receptor substrate 1(IRS1) infer structural instability and functional interference. Journal of biomolecular structure & dynamics, 1–15. Advance online publication. https://doi.org/10.1080/07391102.2023.2187232.

4. Al-Mamun, A., Ahammad, I., Ahmed, S. S., Akter, F., Hossain, S. I., Chowdhury, Z. M., Bhattacharjee, A., Das, K. C., Keya, C. A., & Salimullah, M. (2023). Pharmacoinformatics and molecular dynamics simulation approach to identify anti-diarrheal potentials of Centella asiatica (L.) Urb. against Vibrio cholerae. Journal of biomolecular structure & dynamics, 1–14. Advance online publication. https://doi.org/10.1080/07391102.2023.2191736.

5. Ahammad, I., Jamal, T. B., Bhattacharjee, A., Chowdhury, Z. M., Rahman, S., Hassan, M. R., Hossain, M. U., Das, K. C., Keya, C. A., & Salimullah, M. (2023). Impact of highly deleterious non-synonymous polymorphisms on GRIN2A protein's structure and function. PloS one, 18(6), e0286917. https://doi.org/10.1371/journal.pone.0286917\

6. Bhattacharjee, A., Ahammad, I., Chowdhury, Z.M., Das, K.C., Keya, C.A. and Salimullah, Md. (2022). Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease. Molecular Biotechnology. doi:10.1007/s12033-022-00595-w.

7. Hossain, M.U., Ferdous, N., Reza, M.N., Ahammad, I., Tiernan, Z., Wang, Y., O’Hanlon, F., Wu, Z., Sarker, S., Mohiuddin, A.K.M., Das, K.C., Keya, C.A. and Salimullah, Md. (2022b). Pathogen-driven gene expression patterns lead to a novel approach to the identification of common therapeutic targets. Scientific Reports, 12(1). doi:10.1038/s41598-022-25102-8.

8. Islam, Md.S., Hossain, A., Islam, M., Munshi, M.K., Hussain, M.S., Chandra Das, K., Ahmed, I., Islam Khan, Md.S. and Huque, R. (2022a). Impact of gamma radiation, potassium sorbate and low temperature on shrimp (Penaeus monodon) preservation. Heliyon, 8(12), p.e12596. doi:10.1016/j.heliyon.2022.e12596.

9. Jahan, N., Wasim, M., Rubaya, R., Radeen, K.R., Alim, Md.A., Hossain, M.M.K., Zohora, F.T., Das, K.C., Salimullah, Md., Bhuyan, A.A. and Alam, J. (2022). Sequence variability of CatSper1 and TNP2 gene in indigenous and crossbred cattle in Bangladesh. Animal Biotechnology, pp.1–10. doi:10.1080/10495398.2022.2063729.

10. Rahman, Md.H., Shamsuzzaman, M., Ahmed, I., Moniruzzaman, Md., Amin, U.S.M., Hossain, M.U., Das, K.C., Keya, C.A. and Salimullah, Md. (2022). Association of metallothionein 1A gene polymorphism rs8052394 with type 2 diabetes mellitus in Bangladeshi population. Human Gene, 34, p.201098. doi:10.1016/j.humgen.2022.201098.

11. Sultana, S., Hasan, Md.M., Hossain, Md.S., Alim, Md.A., Das, K.C., Moniruzzaman, Md., Rahman, Md.H., Salimullah, Md. and Alam, J. (2022). Assessment of genetic diversity and population structure of Tenualosa ilisha in Bangladesh based on partial sequence of mitochondrial DNA cytochrome b gene. Ecological Genetics and Genomics, 25, p.100139. doi:10.1016/j.egg.2022.100139.

12. Shaha, M., Majumder, S., Hossain, M.S., Jahan, M., Rahmat, R., Asma, R., Islam, M.A., Rahman, Md.H., Das, K.C., Sarker, P.K., Mahtab, M.A., Akbar, S.M.F. and Salimullah, M. (2022). Identification of a novel variant of hepatitis B virus isolated from patient co-infected with hepatitis C virus. Virus Research, 319, p.198859. doi:10.1016/j.virusres.2022.198859.

13. Das, K.C., Hossain, M.U., Moniruzzaman, M., Salimullah, M. and Akhteruzzaman, S. (2022). High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis. BioMed Research International, 2022, pp.1–17. doi:10.1155/2022/4558867.

14. Amin US, Parvez N, Rahman TA, Hasan M, Das KC, Jahan S, Hasanat MA, Seraj ZI, Salimullah M. CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis. Diabetology & Metabolic Syndrome. 2022 Dec;14(1):1-1. doi:10.1186/s13098-021-00782-w.

15. Hossain, M.U., Ahammad, I., Bhattacharjee, A., Chowdhury, Z.M., Rahman, A., Rahman, T.A., Omar, T.M., Hasan, M.K., Islam, M.N., Hossain Emon, M.T., Chandra Das, K., Keya, C.A. and Salimullah, M. (2022a). Protein-protein interactions network model underlines a link between hormonal and neurological disorders. Informatics in Medicine Unlocked, [online] 28, p.100866. doi:10.1016/j.imu.2022.100866.

16. Ahammad I, Hossain MU, Rahman A, Chowdhury ZM, Bhattacharjee A, Das KC, Keya CA, Salimullah M. Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh. PloS one. 2021 Sep 29;16(9):e0258019. doi:10.1371/journal.pone.0258019.

17. Uzzal Hossain, M., Ahammad, I., Bhattacharjee, A., Mahmud Chowdhury, Z., Emon, M.T.H., Das, K.C., Ara Keya, C. and Salimullah, M. (2021). Whole genome sequencing for revealing the point mutations of SARS-CoV-2 genome in Bangladeshi isolates and their structural effects on viral proteins. RSC Advances, [online] 11(61), pp.38868–38879. doi:10.1039/D1RA05327B.

18. Rahman, A., Susmi, T.F., Yasmin, F., Bhattacharjee, A., Hossain, M.U., Das, K.C., Keya, C.A. and Salimullah, Md. (2021a). Unveiling ancestral relations, host–pathogen interactions and comparative viral miRNA insights of dengue virus serotypes. Network Modeling Analysis in Health Informatics and Bioinformatics, 10(1). doi:10.1007/s13721-021-00297-4.

19. Hossain, M.U., Bhattacharjee, A., Emon, Md.T.H., Chowdhury, Z.M., Ahammad, I., Mosaib, Md.G., Moniruzzaman, Md., Rahman, Md.H., Islam, Md.N., Ahmed, I., Amin, Md.R., Rashed, A., Das, K.C., Keya, C.A. and Salimullah, Md. (2021). Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics. Journal of Genetic Engineering and Biotechnology, 19(1). doi:10.1186/s43141-021-00152-z.

20. Rahman M, Islam MA, Das KC, Salimullah M, Mollah MZ, Khan RA. Effect of gamma radiation on microbial load, physico-chemical and sensory characteristics of common spices for storage. Journal of Food Science and Technology. 2021 Sep;58(9):3579-88. doi:10.1007/s13197-021-05087-4.

21. Hossain MU, Bhattacharjee A, Emon MT, Chowdhury ZM, Mosaib MG, Mourin M, Das KC, Keya CA, Salimullah M. Recognition of plausible therapeutic agents to combat COVID-19: an Omics data based combined approach. Gene. 2021 Mar 1;771:145368. https://doi.org/10.1016/j.gene.2020.145368.

22.  Haque MA, Ashik MA, Aktar S, Akter MS, Halilu A, Haque MA, Islam MR, Abdullah-Al-Mamun M, Nahar MN, Das SR, Das KC. Rapid Deconstruction of Cotton, Coir, Areca, and Banana Fibers Recalcitrant Structure Using a Bacterial Consortium with Enhanced Saccharification. Waste and Biomass Valorization. 2020 Nov 7:1-8. https://doi.org/10.1007/s12649-020-01294-w.

23. Moniruzzaman, M., Hossain, M.U., Islam, M.N., Rahman, M.H., Ahmed, I., Rahman, T.A., Bhattacharjee, A., Amin, M.R., Rashed, A., Keya, C.A., Das, K.C. and Salimullah, M. (2020). Coding-Complete Genome Sequence of SARS-CoV-2 Isolate from Bangladesh by Sanger Sequencing. Microbiology Resource Announcements, 9(28). doi:10.1128/mra.00626-20.

24. Karim, Md.E., Sharmin, S.A., Moniruzzaman, Md., Fardous, Z., Das, K.C., Banik, S. And Salimullah, Md. (2020b). Biotransformation of chromium (VI) by Bacillus sp. isolated from chromate contaminated landfill site. Chemistry and Ecology, 36(10), pp.922–937. doi:10.1080/02757540.2020.1799992.

25. Azad, R., Hamza, A., Khatun, M.M., Nasrin, S., Tanny, T., Das, K.C., Salimullah, M. and Alam, I. (2020). First Report of Colletotrichum siamense Causing Leaf Spot in Aloe vera in Bangladesh. Plant Disease, 104(11), p.3058. doi:10.1094/pdis-04-20-0857-pdn.

26. Karim, M.E., Dhar, K., Md Moniruzzaman, Hossain, M.U., Das, K.C. and Hossain, M.T. (2020a). Decolorization of Synthetic Dyes by Aspergillus flavus Strain EF-3 Isolated from Textile Dyeing Sludge. Bangladesh Journal of Microbiology, 37(1), pp.7–13. doi:10.3329/bjm.v37i1.51203.

27. Moniruzzaman, Md., Ahmed, I., Huq, S., All Mahmud, Md.S., Begum, S., Mahzabin Amin, U.S., Rahman, Md.H., Sarker, P.K., Hossain, M.U., Das, K.C. and Salimullah, Md. (2019). Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population. Molecular Genetics & Genomic Medicine, 8(2). doi:10.1002/mgg3.1073.

28. Al Sanjee S, Haque A, Banerjee S, Hoque MS, Moniruzzaman M, Das KC, Karim ME. Phenotypic and genotypic screening of multi-drug resistant ESBL producing Escherichia coli and Klebsiella pneumoniae from burn-wound infection. International Journal of Biosciences. 2020;16(5):145-155. http://dx.doi.org/10.12692/ijb/16.5.145-155.

29. Islam MJ, Sarker TC, Jebin RA, Yasmin F, Khatun M, Islam MA, Ramzan SB, Nobel FA, Akter S, Islam M, Hasan MM, Khatun MM, Yesmin S, Sabrina S, Khatun M, Mamun AA, Islam MK, Asaduzzaman M, Das KC, Amin MB, Uddin MKM. Determination of Optimum Survivability Factors of Highly Pathogenic Vibrio cholerae 01 Serogroup-Specific Bacteriophage JSF4ϕ. American Journal of Pure and Applied Biosciences. 2020;2(2):8–14. https://doi.org/10.34104/ajpab.020.08014.

30. Karim, Md.E., Sanjee, S.A., Mahmud, S., Shaha, M., Moniruzzaman, Md. and Das, K.C. (2019). Microplastics pollution in Bangladesh: current scenario and future research perspective. Chemistry and Ecology, 36(1), pp.83–99. doi:10.1080/02757540.2019.1688309.

31. Shaha, M., Sarker, P.K., Hossain, Md.S., Das, K.C., Jahan, M., Dey, S.K., Tabassum, S., Hashem, A. and Salimullah, Md. (2018c). Analysis of the complete genome of hepatitis B virus subgenotype C2 isolate NHB17965 from a HBV infected patient. F1000Research, 7, p.1023. doi:10.12688/f1000research.15090.3.

32. Hossain, M.U., Keya, C.A., Das, K.C., Hashem, A., Omar, T.Md., Khan, Md.A., Rakib-Uz-Zaman, S.M. and Salimullah, Md. (2018a). An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus. Frontiers in Chemistry, 6. doi:10.3389/fchem.2018.00246.

33. Begum M, Hamza A, Tanny T, Das KC, Mahmud MT, Salimullah M, Alam I. First Report of Leaf Spot Disease in Aloe vera Caused by Nigrospora oryzae in Bangladesh. Plant Disease. 2018 Jul 18;102(7):1461. https://doi.org/10.1094/PDIS-11-17-1857-PDN.

34. Hossain, M.U., Omar, T.Md., Alam, I., Das, K.C., Mohiuddin, A.K.M., Keya, C.A. and Salimullah, Md. (2018b). Pathway based therapeutic targets identification and development of an interactive database CampyNIBase of Campylobacter jejuni RM1221 through non-redundant protein dataset. PLOS ONE, 13(6), p.e0198170. doi:10.1371/journal.pone.0198170.

35. Shaha, M., Das, K.C., Hossain, M.S., Jahan, M., Hashem, A., Rahman, S.R. and Salimullah, M. (2018a). Complete Genome Sequence of a Circulating Hepatitis B Virus Genotype C Strain Isolated from a Chronically Infected Patient Identified at an Outdoor Hospital in Bangladesh. Genome Announcements, 6(9). doi:10.1128/genomea.01601-17.

36. Barman NC, Zohora FT, Das KC, Mowla MG, Banu NA, Salimullah M, Hashem A. Production, partial optimization and characterization of keratinase enzyme by Arthrobacter sp. NFH5 isolated from soil samples. AMB Express. 2017 Dec 1;7(1):181. DOI 10.1186/s13568-017-0462-6.

37. Hossain MU, Das KC, Amin UM, Keya CA, Salimullah M. Sorting Out Non-Synonymous Single Nucleotide Polymorphism Leads to Novel Biomarker Discovery for Disease Prognosis. Curr Trends Biomedical Eng & Biosci. 2017 April 24;3:2. DOI: 10.19080/CTBEB.2016.01.555608.

38. Raval IH, Das KC, Haldar S. Collection of mullet fish (Mugil cephalus) from west coast of India: evaluation of its quality with relation to food safety. Environmental Science and Pollution Research. 2017 Apr 1;24(11):10833-45. https://doi.org/10.1007/s11356-017-8555-y.

39. Hossain MM, Das KC, Yesmin S, Shahriar S. Effect of plant growth promoting rhizobacteria (PGPR) in seed germination and root-shoot development of chickpea (Cicer arietinum L.) under different salinity condition. Research in Agriculture Livestock and Fisheries. 2016 May 26;3(1):105-13.

40. Hossain MM, Das KC, Yesmin S, Shahriar S, Uddin MJ. Islolation and Characterization of Plant Rhizoplane-Rhizosphere Probiotics and their Effect on Growth and Yield of Chilli. Journal of Experimental Biosciences. 2015;6(2):67-72.

41. Yesmin S, Hashem A, Das KC, Hasan MM, Islam MS. Efficient in vitro regeneration of chrysanthemum (Chrysanthemum morifolium Ramat.) through nodal explant culture. Nuclear science and applications. 2014;23(1&2):47-50.

42. Banik S, Das KC, Islam MS and Salimullah M. Recent Advancements and Challenges in Microbial Bioremediation of Heavy Metals Contamination. Review Article. JSM Biotechnology & Biomedical Engineering. 2014;2(1):1035.

43. Nasrin S, Das KC, Rahman F, Hashem A, Yesmin S, Islam MS. Mass Production of Strawberry Plants Through Microporpagation. Eco-friendly Agriculture Journal. 2010;3(7):340-344.

44. Rahman F, Das KC, Nasrin S, Khan ZUM. Effect of Azospirillum spp. on the Physiological, Yield and Biochemical Parameters of Wheat Cultivar, Shatabdi. Eco-friendly Agriculture Journal. 2010;3(7):327-333.

45. Rahman MS, Das KC, Das DK, Biswas K, Chowdhury MB, Karim NH, Salam MA, Seraj ZI. Breeding and anther derived lines of rice (Oryza sativa L.) for saline coastal areas of Bangladesh. Bangladesh Journal of Botany. 2010;39(1):71-8.

46. Das KC, Rahman MS, Siddiquee MA, Seraj ZI. Analysis of Anther Derived Rice (Oryza sativa L.) Genotypes for Their Tolerance to Salinity. Eco-friendly Agriculture Journal. 2010;3(5):254-260.

47. Rahman F, Das KC, Nasrin S, Khan ZUM. Physiological Characteristics and Biological Nitrogen Fixation of Azospirillum spp., Isolated from Three Locations in Bangladesh. Eco-friendly Agriculture Journal. 2010;3(5):247-253.

48. Sarker PK, Sarker BC, Das KC, Sana NK. Antibody Response to Helicobacter pylori among Patients with Suspected Gastric Disease. Bangladesh Journal of Medical Science. 2010;16(1):39-42.

49. Das KC, Sarker BC, Sarker PK, Sana MK, Islam MS, Sayeed MA, Choudhury S. Thyroid Dysfunction in a Cross Section of Population in Dhaka City. Bangladesh Journal of Medical Science. 2010;16(1):19-23.

50. Elahi CF, Seraj ZI, Rasul NM, Das KC, Biswas K, Salam MA, Gomosta AR, Tumimbang E, Adorada D, Gregorio G, Bennett J. Breeding rice for salinity tolerance using the Pokkali allele: finding a linked DNA marker. vitro. 2004 Jan 1:157-70.

51. Lisa LA, Seraj ZI, Elahi CF, Das KC, Biswas K, Islam MR, Salam MA, Gomosta AR. Genetic variation in microsatellite DNA, physiology and morphology of coastal saline rice (Oryza sativa L.) landraces of Bangladesh. Plant and Soil. 2004 Jun 1;263(1):213-28.