National Biotechnology Fair-2018
07-08 September 2018
Poster Presentation Competition (research based)
General guidelines:
Abstract format
Poster Format
Award: Best posters will be awarded.
Send to: posternib@gmail.com
Dead line for Submission: 25 July, 2018
Any Query
Mohammad Uzzal Hossain
Scientific Officer, NIB
01772-857289
Poster Presentation Competition (idea based)
General guidelines:
Poster Format
Award: Best posters will be awarded.
Send to: posternib@gmail.com
Dead line for Submission: 25 July, 2018
Any Query
Mohammad Uzzal Hossain
Scientific Officer, NIB
01772-857289
Sample Template of abstract for Poster Presentation
Pathway based therapeutic targets identification and development of an interactive database CampyNIBase of campylobacter jejuni RM1221 through non-redundant protein dataset
Mohammad Uzzal Hossain1, Taimur Md. Omar2, Iftekhar Alam3, Keshob Chandra Das4, A.K.M. Mohiuddin2,Chaman Ara Keya5, Md. Salimullah4*
1Bioinformatics Division, 3Plant Biotechnology Division,4Molecular Biotechnology Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka-1349, Bangladesh
2Department of Biotechnology and Genetic Engineering, Life Science Faculty, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
5Department of Biochemistry and Microbiology, North south University, Bashundhara, Dhaka-1229, Bangladesh
*Corresponding author
Dr. Md. Salimullah
Director General (Additional Charge)
National Institute of Biotechnology
Ganakbari, Ashulia, Savar, Dhaka-1349, Bangladesh
Tel: 880-2-7788443
Fax: 880-2-7789636
E-mail: dgnibbd@gmail.com
Presenting Author
Mohammad Uzzal Hossain
Scientific Officer
Bioinformatics Division
National Institute of Biotechnology
Mob: 01772857289
E-mail: uzzalbge10044@gmail.com
Abstract
The bacterial species Campylobacter jejuni RM1221(CjR) causes campylobacteriosis posing global threat for human health. Antibiotic treatment might be ineffective due to the development of multiple resistances. Therefore, new medicine and drug targets on demand which can be obtained by targeting essential protein(s) of CjR. We conducted this in silico study to identify therapeutic targets by subtractive CjR proteome analysis. The most important proteins of CjR proteome including chokepoint enzymes, plasmid, virulence and antibiotic resistant proteins were annotated and subjected to subtractive analyses to filter out the CjR essential proteins from duplicate or human homologous proteins. Through the subtractive and characterization analysis we have identified 38 eligible therapeutic targets including 1 potential vaccine target. Also, 12 potential targets were found in interactive network, 5 targets to be dealt with FDA approved drugs and one pathway as potential pathway based drug target. In addition, a comprehensive database ‘CampyNIBase’ has also been developed. Besides the results of this study, the database is enriched with other information such as 3D model of the identified targets, experimental structures and Expressed sequence tag (EST) sequences. This study including the database might be exploited for future research and identifying better therapeutics against campylobacteriosis. URL: http://nib.portal.gov.bd/site/page/4516e965-8935-4129-8c3f-df95e754c562#Banner.
Keywords: Campylobacter jejuni RM1221, Proteome, therapeutic targets, Database.
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